Twenty four male guinea-pigs were randomly divided into 3 groups: Group A

allergic asthma guinea-pigs prepared by peritoneal injection and spraying inhalation of albumin; Group B

allergic asthma guinea-pigs treated with electroacupuncture through stimulating the acupoint Feishu (UB13) and Group C

the control group. With[3H]-DHA as a radioligand

pulmonary β-adrenoceptor (β- AC) in the 3 groups of guineapigs were detrermined by radioligand binding assay technique. The results showed that: (1) The maximum binding volume of receptor ligand (Bmax

fmol/mg prot.) of pulmonary β-AC in Group A (123.86 β 42.91) was significantly lower than that in group C (199.54 β 37.03

P<0.05)

while the difference between group B (142.00+42.91) and group C was not significant (P>0.05). (2) The Kd (nM) of pulmonary β-AC in group A

B and C were 5.10 β 1.39

6.53 β 2.41 and 8.72 β 2.02 respectively

and the differences among the three groups were not significant (P>0.05). The results indicated that the decrease of the content and dysfunction of pulmonary β-AC in allergic asthma guinea-pigs might be regulated by electroacupuncture therapy.