The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis

Ke-Ying Zhou; Rong Huang; Pei-Lan Yu; Bao-Lin Zhang; Yu-Jia Yang; Pei-Fang Zhou; Yi-Xin Liu

doi:10.1007/BF02934257

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The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis

OriginalPaper | Updated：2021-08-27

- The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis
- The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis
- 中国结合医学杂志（英文版） 1996年2卷第3期页码：215-217
- Affiliations：
  
  1. Department of Pediatrics, Xiangya Hospital, Hunan Medical University,Changsha
  2. Department of Pediatrics, Hospital of Overseas Chinese Town,Shenzhen
- Author bio：
- Funds：
  
  This project is supported by the Scientific Research Funds for Youth granted by the Ministry of Public Health of China, No. 920124
- DOI：10.1007/BF02934257
  中图分类号：
- 纸质出版日期：1996，
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Zhou, KY., Huang, R., Yu, PL. et al. The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis., CJIM 2, 215 (1996). https://doi.org/10.1007/BF02934257

Ke-Ying Zhou, Rong Huang, Pei-Lan Yu, et al. The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis[J]. Chinese Journal of Integrative Medicine, 1996,2(3):215-217.
Zhou, KY., Huang, R., Yu, PL. et al. The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis., CJIM 2, 215 (1996). https://doi.org/10.1007/BF02934257 DOI：

Ke-Ying Zhou, Rong Huang, Pei-Lan Yu, et al. The effect of tetramethylpyrazine on tumor necrosis factor-α, thromboxane A2 and prostacyclin in cerebrospinal fluid of rabbits with bacterial meningitis[J]. Chinese Journal of Integrative Medicine, 1996,2(3):215-217. DOI： 10.1007/BF02934257.

摘要

This study aimed to evaluate the effect of tetramethylpyrazine in treating bacterial meningitis. Experimental model of rabbit meningitis was induced by intracisternal inoculation of 2 x 107 colony-forming units of Escherichia Coli and tumor necrosis factor-α

thromboxane B2 and 6-keto-prostagladin F1α concentrations in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs

27 hrs and 30 hrs after infection. Results showed that tetramethylpyrazine could significantly lower the concentrations of tumor necrosis factor-α and thromboxane B2 in cerebrospinal fluid. Administration of both tetramethylpyrazine and ampicillin could attenuate the antibiotic-induced rapid release of the 2 inflammatory mediators.

Abstract

thromboxane B2 and 6-keto-prostagladin F1α concentrations in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs

关键词

tetramethylpyrazinetumor necrosis factorthromboxaneprostacyclinmeningitiscerebrospinal fluidrabbits

Keywords

tetramethylpyrazinetumor necrosis factorthromboxaneprostacyclinmeningitiscerebrospinal fluidrabbits

references

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Mustafa MM, Ramilo O, Mertsola J, et al. Modulation of inflammation and cachectin activity in relation to treatment of experimental Hemophilus influenzae type B meningitis. The J. of Infectious Disease 1989; 160: 818–24.

Tauber MG, Sachdera M, Kennedy SL, et al. Toxicity in Neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis. The J. of Infectious Disease 1992; 166: 1045–50.

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Mustafa MM, Ramilo O, Saez-Llorens X, et al. Role of tumor necrosis factor alpha in experimental and clinical bacteial meningitis. The Pediatric Infectious Disese Journal 1989; 8: 907–8.

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Mustafa MM, Ramilo O, Saez-Llorens X, et al. Cerebrospinal fluid prostaglandin, interleukin 1β and tumor necrosis factor in bacterial meningitis. AJDC 1990; 144: 883–7.

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