Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment

Hao Xu; Ke-Ji Chen; Da-zhuo Shi; Xiao-chang Ma; Shu-zheng Lu; Jie-ming Mao

doi:10.1007/BF02934299

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Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment

OriginalPaper | Updated：2021-08-27

- Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment
- Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment
- 中国结合医学杂志（英文版） 2002年8卷第3期页码：162-166
- Affiliations：
  
  1. Xiyuan Hospital, China Academy of TCM,Beijing
  2. The Third Hospital Affiliated to Peking University, Health Science Center,USA
  3. Anzhen Hospital Affiliated to Capital University of Medical Sciences,USA
- Author bio：
- Funds：
  
  National Ninth Five-Year Project (No. 96-906-06-01)
- DOI：10.1007/BF02934299
  中图分类号：
- 纸质出版日期：2002，
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Xu, H., Chen, Kj., Shi, Dz. et al. Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment., CJIM 8, 162–166 (2002). https://doi.org/10.1007/BF02934299

Hao Xu, Ke-Ji Chen, Da-zhuo Shi, et al. Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment[J]. Chinese Journal of Integrative Medicine, 2002,8(3):162-166.
Xu, H., Chen, Kj., Shi, Dz. et al. Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment., CJIM 8, 162–166 (2002). https://doi.org/10.1007/BF02934299 DOI：

Hao Xu, Ke-Ji Chen, Da-zhuo Shi, et al. Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment[J]. Chinese Journal of Integrative Medicine, 2002,8(3):162-166. DOI： 10.1007/BF02934299.

摘要

To evaluate the effect of Xiongshao Capsule in preventing clinical and angiographic restenosis after coronary angioplasty or/and stenting. The total of 108 coronary heart disease patients with successful coronary angioplasty or/and stenting were randomly divided into the control group (55 cases

routine treatment) and the XS group (53 cases

routine treatment combined with XS). The recurrence of angina

clinical end-point events

changing of blood-stasis syndrome score (BSSS) and coronary angiography within 6 month after coronary angioplasty or/and stenting were observed. Follow-up angiography was performed in 42 patients including 18 cases in the XS group (restenosis was observed in 7 patients) and 24 cases in the control group (restenosis was observed in 17 patients)

there was significant difference between the occurrence of restenosis in XS and that in control group (P < 0.05). The occurrence of clinical end-point events (death

nonfatal target lesion myocardial infarction

coronary artery bypass graft surgery

or repeat target-vessel angioplasty) in the XS group (18.8%) was significantly lower than that in the control group (40%)(P <0.05). The recurrent angina was observed in 13 cases in the XS group

there was significant difference as compared with 27 cases in the control group (P <0.05). There was also remarkable significance for the difference of base-line and follow-up BSSS between groups (P < 0. 01). Logistic multivariate stepwise regress analysis and multivariate regress analysis of the related factors with restenosis confirmed by coronary angiography showed that

the base-line BSSS and the difference of base-line and follow-up BSSS were important influencing factors on the occurrence of restenosis after interventional treatment (P < 0.05). XS could markedly reduce the occurrence of angiographic restenosis

clinical end-point events and recurrent angina

improve condition of blood-stasis after coronary angioplasty or/and stenting. The severity of blood-stasis syndrome was an important influencing factor on the occurrence of restenosis. It still needs to be further demonstrated by large-scale

double-blinded

randomized and controlled study.

Abstract

routine treatment) and the XS group (53 cases

routine treatment combined with XS). The recurrence of angina

clinical end-point events

there was significant difference between the occurrence of restenosis in XS and that in control group (P < 0.05). The occurrence of clinical end-point events (death

nonfatal target lesion myocardial infarction

coronary artery bypass graft surgery

or repeat target-vessel angioplasty) in the XS group (18.8%) was significantly lower than that in the control group (40%)(P <0.05). The recurrent angina was observed in 13 cases in the XS group

clinical end-point events and recurrent angina

double-blinded

randomized and controlled study.

关键词

Xiongshao capsuleangioplastystentrestenosis

Keywords

Xiongshao capsuleangioplastystentrestenosis

references

Hong MK, Mehran R, Mintz GS, et al. Restenosis after coronary angioplasty. Current Problem in Cardiology 1997; 22(l):7–36.

Shi DZ, Xu FQ, Ma XC, et al. The experimental study of Xue Guan Tong on preventing restenosis after percutaneous transluminal angioplasty. Chin J Integr Med 1995; 1 (4):284–287.

Shi DZ, LI J, Ma XC, et al. Clinical observation of concentrated Xufu Zhuyu Pill on preventing restenosis after percutaneous transluminal coronary angioplasty in patients of coronary heart disease. Chin J of TCM 1997;38(1):27–29.

Xu H, Shi DZ, Chen KJ, et al. Effect of Xiongshao capsule on vascular remodeling in porcine coronary balloon injury model. Chin J Integr Med 2001 ;21(8): 591–594.

Xu H, Shi DZ, Chen KJ, et al. Effect of XS0601 on apoptosis and gene expression of p53 and bcl-2 in neointima of porcine coronary artery after balloon injury. Chin J In-terventional Cardiology 2001;9(3): 152–154.

Xu H, Shi DZ, Chen KJ, et al. Effect of Xiongshao capsule on proliferation and apoptosis of vascular smooth muscle cells in rabbits observed by serologic pharmacological method. Chin J Integr Med 2000;20(10): 757–760.

Chen HZ edited. Internal Medicine. 1st Edition. Beijing: The People’s Health Publishing House, 1995:263–264.

The Speciality Committee of Promoting Blood Circulation and Removing Blood-Stasis of Chinese Association of Integrative Western and Chinese Medicine. The Diagnostic Criteria of Blood-stasis Syndrome. Chin J Integr Med 1987; 7 (3):129.

Wang J. Study on diagnostic criteria of blood-stasis syndrome. Research and Clinical Application of Promoting Blood Circulation and Removing Blood-Stasis. 1st Edition. Beijing: The United Publishing House of Beijing Medical University and China Union Medical University, 1993:7.

Chen ZJ edited. Clinical coronary heart disease. 1st edition. Beijing: Publishing House of People Military Surgeon, 1994: 345–351.

Yu B, Chen KJ, Mao JM, et al. Clinical study of concentrated Xuefu Zhuyu Pill on preventing restenosis after coronary stenting in patients of coronary heart disease. Chin J Integr Med 1998; 18(10):585–589.

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