Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications

Ding-guo Yao; Su-sheng Luo; Hai-xiang Ni; Jia-ping Wei; Cui-ying Zheng

doi:10.1007/BF02934305

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Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications

OriginalPaper | Updated：2021-08-27

- Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications
- Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications
- 中国结合医学杂志（英文版） 2002年8卷第3期页码：183-185
- Affiliations：
  
  Department of Endocrinology, Zhejiang Provincial TCM Hospital,Hangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02934305
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- 纸质出版日期：2002，
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Yao, Dg., Luo, Ss., Ni, Hx. et al. Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications., CJIM 8, 183–185 (2002). https://doi.org/10.1007/BF02934305

Ding-guo Yao, Su-sheng Luo, Hai-xiang Ni, et al. Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications[J]. Chinese Journal of Integrative Medicine, 2002,8(3):183-185.
Yao, Dg., Luo, Ss., Ni, Hx. et al. Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications., CJIM 8, 183–185 (2002). https://doi.org/10.1007/BF02934305 DOI：

Ding-guo Yao, Su-sheng Luo, Hai-xiang Ni, et al. Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications[J]. Chinese Journal of Integrative Medicine, 2002,8(3):183-185. DOI： 10.1007/BF02934305.

摘要

To study the changes of endothelin (ET)

tumor necrosis factor-α (TNF-a) before and after puerarin treatment in patients with diabetes mellitus vascular complications (DMVC). Ninety-eight DMVC patients were divided into 2 groups

they were given puerarin (n= 68) and normal saline (n = 30) respectively

20 diabetic patients without vascular complications (NDMVC) were taken as control

who were also given puerarin. All the patients were treated on the basis of controlling blood glucose. Plasma ET and serum TNF-α were determined by radioimmunoassay (RIA) before and after treatment. Plasma ET and serum TNF-a in DMVC got higher than that of NDMVC patients (p <0.05)

and ET level was correlated with TNF-a (r = 0.69

r = 0.73

p <0.01). After treatment

the levels of ET and TNF-a were significantly lower than those before treatment of DMVC patients with puerarin (p < 0. 05). Puerarin could regulate the levels of plasma ET and serum TNF-α of DMVC patients

suggesting that it has the function of regulating endothelial cells.

Abstract

To study the changes of endothelin (ET)

tumor necrosis factor-α (TNF-a) before and after puerarin treatment in patients with diabetes mellitus vascular complications (DMVC). Ninety-eight DMVC patients were divided into 2 groups

they were given puerarin (n= 68) and normal saline (n = 30) respectively

20 diabetic patients without vascular complications (NDMVC) were taken as control

and ET level was correlated with TNF-a (r = 0.69

r = 0.73

p <0.01). After treatment

suggesting that it has the function of regulating endothelial cells.

关键词

Puerarintype 2 diabetes mellitusvascular complicationendothelintumor necrosis factor-α

Keywords

Puerarintype 2 diabetes mellitusvascular complicationendothelintumor necrosis factor-α

references

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Huang JZ, Wang J, Zhang Z, et al. The significance of endothelial cell vascular injury to the diabetes mellitus vascular lesion. Chin J Endocrin 2000; 16(3): 169–171.

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Klemm P, Warner TD, Hohlfeld T, et al. Endothelin mediates in vivo coronary vasoconstriction caused by exogenous and endogenous cytokines. Proc Natl Acad Sci USA 1995; 92(7):269–272.

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