Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin

LU Kong; Xi-wei Zhou; EN Li; Wei-Jian Feng; Zan Sheng; Jing-zhi He

doi:10.1007/BF02934307

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Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin

OriginalPaper | Updated：2021-08-27

- Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin
- Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin
- 中国结合医学杂志（英文版） 2002年8卷第3期页码：191-194
- Affiliations：
  
  1. Department of Biochemistry, Hebei Medical University,Shijiazhuang
  2. Chemotherapy Department, The Fourth Hospital of Hebei Medical University,China
  3. Department of Immunology, Hebei Medical University,China
- Author bio：
- Funds：
- DOI：10.1007/BF02934307
  中图分类号：
- 纸质出版日期：2002，
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Kong, L., Zhou, Xw., Li, E. et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin., CJIM 8, 191 (2002). https://doi.org/10.1007/BF02934307

LU Kong, Xi-wei Zhou, EN Li, et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin[J]. Chinese Journal of Integrative Medicine, 2002,8(3):191-194.
Kong, L., Zhou, Xw., Li, E. et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin., CJIM 8, 191 (2002). https://doi.org/10.1007/BF02934307 DOI：

LU Kong, Xi-wei Zhou, EN Li, et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin[J]. Chinese Journal of Integrative Medicine, 2002,8(3):191-194. DOI： 10.1007/BF02934307.

摘要

To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS

) in antagonizing nephrotoxicity and hematological toxicity by cisplatin (CDDP). The patients with different types of carcinomas were divided into two groups. One group was treated by western medicine (WM)

i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy

YQJPBS was given orally. Urinary enzyme (NAG

Y-GT

ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. The early renal damage by CDDP remains near proximal convoluted tubule

which leads to the rising of urinary enzyme. So urinary enzyme of the CM group was obviously lower than that of the WM group. The lesion of renal interstitial cells that produce Epo did not cause the serum Epo of WM group to rise obviously 15 days later. As a result there was 40% patients whose RBC and Hb became lower than the standard count. While serum Epo of CM group was higher than that of WM group

only 5% patients in the CM group had their RBC and Hb lowered. YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.

Abstract

To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS

i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy

YQJPBS was given orally. Urinary enzyme (NAG

Y-GT

ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. The early renal damage by CDDP remains near proximal convoluted tubule

only 5% patients in the CM group had their RBC and Hb lowered. YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.

关键词

Yiqi Jianpi Bushen recipecisplatinnephrotoxicityurinary enzymeerythropoietin

Keywords

Yiqi Jianpi Bushen recipecisplatinnephrotoxicityurinary enzymeerythropoietin

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