Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells

Huai-yu Wang; Shan-xi Liu

doi:10.1007/BF02934308

Your Location：

Home >

Browse articles >

Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells

OriginalPaper | Updated：2021-08-27

- Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells
- Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells
- 中国结合医学杂志（英文版） 2002年8卷第3期页码：195-199
- Affiliations：
  
  Department of Hematology, the First Hospital of Xi’ an Jiao-tong University,Xi’an
- Author bio：
- Funds：
  
  This project is subsidized by Chinese Medicine Foundation of Shaanxi Province, No. 1999002
- DOI：10.1007/BF02934308
  中图分类号：
- 纸质出版日期：2002，
Scan for full text
Wang, Hy., Liu, Sx. Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells., CJIM 8, 195–199 (2002). https://doi.org/10.1007/BF02934308

Huai-yu Wang, Shan-xi Liu. Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells[J]. Chinese Journal of Integrative Medicine, 2002,8(3):195-199.
Wang, Hy., Liu, Sx. Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells., CJIM 8, 195–199 (2002). https://doi.org/10.1007/BF02934308 DOI：

Huai-yu Wang, Shan-xi Liu. Modulation of gene expression networks underlying Realgar-Induced differentiation of acute promyelocytic leukemia cells[J]. Chinese Journal of Integrative Medicine, 2002,8(3):195-199. DOI： 10.1007/BF02934308.

摘要

To elucidate the molecular mechanism of the differentiation of acute promyelocytic leukemia (APL) cell line NB4 induced by realgar. The response of NB4 cell to realgar was explored with a cDNA microarray representing 1003 different human genes. The analysis of gene expression profiles indicated that 8 genes were up-regulated and 33 genes were down-regulated 48 hrs after realgar treatment. Among the 8 up-regulated genes

2 genes were involved in ubiquitin proteasome degradation pathway. Some genes related to RNA processing

protein synthesis and signal transduction were down-regulated. The ubiquitin-proteasome degradation pathway may play an important role in the degradatipn of PML/ RAR a fusion protein and the differentiation of NB4 cells.

Abstract

2 genes were involved in ubiquitin proteasome degradation pathway. Some genes related to RNA processing

关键词

realgarDNA microarrayAcute Promyelocytic Leukemia

Keywords

realgarDNA microarrayAcute Promyelocytic Leukemia

references

Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide (AS2O3) in the treatment of acute promyelocytic leukemia (APL), II: Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997; 89:3354–3360.

Lu DP, Qiu JY, Jiang B, et al. Tetra-arsenic tetra-sul-fide for the treatment of acute promyelocytic leukemia: a pilot report. Blood 2002;99:3136–3143.

Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem 1996; 65:801–847.

Marchansky V, Wang X, Bertrand R, et al. Proteasomes modulates balance among proapoptotic and antiapoptotic bcl-2 family members and compromise functioning of the electron transport chain in leukemic cell. J Immunol 2001; 166:3130–3142.

Lallemand Breitenbach V, Zhu J, Puvion F, et al. Role of promyelocytic leukemia (PML) simulation in nuclear body formation, 11S proteasome recruitment, and AS2O3-in-duced PML or PML/retinoic acid receptor alpha degradation. J Exp Med 2001; 193:1361–1371.

Zhu J, Gianni M, Kopf E, et al. Retinoic acid induces proteasomedependent degradation of retinoic acid receptor a (RARα) and oncogenic RARα fusion proteins. Proc Natl Acad Sci USA 1999; 96:14807–14812.

Fanelli M, Minucci S, Gelmetti V, et al. Constitutive degradation of PML/RAR alpha through the proteasome pathway mediates retinoic acid resistance. Blood 1999; 93:1477–1481.

Kay GF, Ashworth A, Penny GD, et al. A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme El. Nature 1991; 354:486–489.

Liu TX, Zhang JW, Tao J, et al. Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Blood 2000:96:1496 -1504.

Gusarova Viktoria, Caplan Avrom J, Brodsky Jeffrey L, et al. Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70. J Biol Chem 2001; 276: 24891–24900.

Imamura T, Haruta T, Takata Y, et al. Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. J Biol Chem 1998 ;273:11183–11188.

Liu J, Kadiiska MB, Liu Y, et al. Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol Sci 2001;61:314–320.

Tirone F. The gene PC3(TIS2l/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? J Cell Physiol 2001; 187:155–165.

Kannan K, Amariglio N, Rechavi G, et al. DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 2001; 20:2225–2234.

Rouault JP, Falette N, Guehenneux F, et al. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nature Genet 1996;14:482–486.

Ficazzola MA, Fraiman M, Gitlin J, et al. Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis. Carcinogenesis 2001 ;22:1271–1279.

Monaco C, Negrini M, Sozzi G, et al. Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 1lq23. Genomics 1997; 46:217–222.

Rommens JM, Durocher F, McArthur J, et al. Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. Genomics 1995; 28: 530–542.

Das BK, Xia L, Palandjian L, et al. Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol Cell Biol 1999; 19: 6796- 6802.

Schmauss C, Brines ML, and Lerner MR. The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons. J Biol Chem 1992; 267:8521–8529.

Cruzen ME and Arfin SM. Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase. DNA Seq 1994;4:243–248.

Wakasugi K and Schimmel P. Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science 1999;284:147–151.

Dejgaard K, Leffers H, Rasmussen HH, et al. Identification, molecular cloning, expression and chromosome mapping of a family of transformation up-regulated hnRNP-K proteins derived by alternative splicing. J Mol Biol 1994; 236:33–48.

FULL TEXT LINK

More>

浏览量

413

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Realgar-induced apoptosis of cervical cancer cell line Siha via cytochrome c release and caspase-3 and caspase-9 activation

Clinical observation of the treatment of myelodysplastic syndrome mainly with Qinghuang Powder (青黄散)

Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies

Advances in management of acute promyelocytic leukemia with arsenic trioxide

Effects of langchuangjing granule on apoptotic of CD4 + T and CD19 + B in spleen of BXSB mice with systemic lupus erythematosus