Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens

Rui-qin Qian; Chun-ying Zhang; Hong-zheng Fu; Wen-han Lin; Zi-fen Gao

doi:10.1007/BF02934311

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Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens

OriginalPaper | Updated：2021-08-27

- Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens
- Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens
- 中国结合医学杂志（英文版） 2002年8卷第3期页码：204-207
- Affiliations：
  
  Department of Integrative Chinese and Western Medicine, Health and Science Center of Peking University,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02934311
  中图分类号：
- 纸质出版日期：2002，
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Qian, Rq., Zhang, Cy., Fu, Hz. et al. Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens., CJIM 8, 204–207 (2002). https://doi.org/10.1007/BF02934311

Rui-qin Qian, Chun-ying Zhang, Hong-zheng Fu, et al. Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens[J]. Chinese Journal of Integrative Medicine, 2002,8(3):204-207.
Qian, Rq., Zhang, Cy., Fu, Hz. et al. Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens., CJIM 8, 204–207 (2002). https://doi.org/10.1007/BF02934311 DOI：

Rui-qin Qian, Chun-ying Zhang, Hong-zheng Fu, et al. Study on therapeutic mechanism of anti-rheumatism effect of siegesbeckia pubescens[J]. Chinese Journal of Integrative Medicine, 2002,8(3):204-207. DOI： 10.1007/BF02934311.

摘要

To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens (AFSP). Adjuvant arthritis (AA) model of rat was produced to observe the effect of AFSP on lymphocyte proliferation

interleukin-1 and -2 (IL-1

-2) activity

pathologic section of ankle joint

and analgesic effect

in model rat. AFSP could reduce the inflammatory pathologic response of ankle joint. It has good analgesic effect

the analgesic rate being 65% . AFSP could also strengthen T-lymphocyte proliferation

promote IL-2 activity and inhibit IL-1 activity. Compared with the control group

the difference was significant (P<0.01). By means of regulating the immune function of organism

AFSP could improve the local pathologic response to antagonize against rheumatism

therefore

it is an effective anti-rheumatism herbal medicine.

Abstract

interleukin-1 and -2 (IL-1

-2) activity

pathologic section of ankle joint

and analgesic effect

in model rat. AFSP could reduce the inflammatory pathologic response of ankle joint. It has good analgesic effect

the analgesic rate being 65% . AFSP could also strengthen T-lymphocyte proliferation

promote IL-2 activity and inhibit IL-1 activity. Compared with the control group

the difference was significant (P<0.01). By means of regulating the immune function of organism

AFSP could improve the local pathologic response to antagonize against rheumatism

therefore

it is an effective anti-rheumatism herbal medicine.

关键词

active fraction of Siegesbeckia pubescensimmunityanti-rheumatism

Keywords

active fraction of Siegesbeckia pubescensimmunityanti-rheumatism

references

Chen Qedited. Methodology of Chinese drugs pharmacologic study. Beijing: People’s Health Publishing House, 1993: 369–370, 772-773, 378-379.

Zhou DH, Shen YS, Zhao MR. New assay to determine lymphocyte transformation and interleukin-2 activity — MTT colorimetry analysis. Chin J Immun 1986; 2(1): 39–44.

Friedrich Hasle edited. TIAN YF translated. New progress in rheumatology. Chengdu: Sichuan Science and Technology Press, 1992: 3-24.

Li J, Tang XL, CHEN MZ, et al. The immune regulating mechanism of white peony glycosides in treating adjuvant arthritis rats. Chin Pharmacol Bull 1995; 11(4): 475–477.

Zhou JH, Li XY, RONG KT chief edited. Progress in immune pharmacology: basis and clinical practice. Beijing: Chinese Science and Technology Press, 1993: 420–421.

Binderup L. Lymphocyte-macrophage cooperation during induction of T suppressor cell activity in rats with adjuvant arthritis. Ann Rheum Dis 1993: 42–683.

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