Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice

Yong-Gang Xu; Rou Ma; Nai-ping Hu; Feng Liu; Jing-min Yang; Ling Ma; Xiao-mei Hu

doi:10.1007/BF02934372

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Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice

OriginalPaper | Updated：2021-08-27

- Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice
- Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice
- 中国结合医学杂志（英文版） 2001年7卷第4期页码：283-287
- Affiliations：
  
  Xiyuan Hospital, China Academy of TCM,Beijing
- Author bio：
- Funds：
  
  This study was supported by State Administration of TCM (No. 922153);and won the 3rd grade Award of 1998’ Scientific and Technological Advancement of China Academy of TCM
- DOI：10.1007/BF02934372
  中图分类号：
- 纸质出版日期：2001，
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Xu, Yg., Ma, R., Hu, Np. et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice., CJIM 7, 283–287 (2001). https://doi.org/10.1007/BF02934372

Yong-Gang Xu, Rou Ma, Nai-ping Hu, et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice[J]. Chinese Journal of Integrative Medicine, 2001,7(4):283-287.
Xu, Yg., Ma, R., Hu, Np. et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice., CJIM 7, 283–287 (2001). https://doi.org/10.1007/BF02934372 DOI：

Yong-Gang Xu, Rou Ma, Nai-ping Hu, et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice[J]. Chinese Journal of Integrative Medicine, 2001,7(4):283-287. DOI： 10.1007/BF02934372.

摘要

To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and explore its mechanism. MRL model mice were established by hypodermic inoculation with L7212 cells 1×106 following intraperitoneal injection of cytoxan (CTX) 250 mg/kg 3 days later

and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets

including CD3 +

CD4 + and CD8 +

and the survival time in model mice were observed. Compared with the control

FZKBG could obviously increase both the percentage and absolute value of CD3 + and CD4 + lymphocytes and prolong the survival time of model mice

the prolongation rate being 29. 6% – 60. 4%. FZKBG could markedly prolong the survival time of MRL mice

and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.

Abstract

and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets

including CD3 +

CD4 + and CD8 +

and the survival time in model mice were observed. Compared with the control

FZKBG could obviously increase both the percentage and absolute value of CD3 + and CD4 + lymphocytes and prolong the survival time of model mice

the prolongation rate being 29. 6% – 60. 4%. FZKBG could markedly prolong the survival time of MRL mice

and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.

关键词

Fuzheng Kangbai Granuleminimal residual leukemiaimmune function

Keywords

Fuzheng Kangbai Granuleminimal residual leukemiaimmune function

references

Ma R, Liu F, Xue XJ. The understanding and treatment on minimal residual leukemia in TCM. Chin J TCM 1994;35(12):748–750.

Ma R, Liu F, Yang JM, et al. Clinical study on effect of Fuzheng Kangbai Granule on long-term survival of acute leukemia patients. Chin J Integr Med 1998; 18(5): 276–278.

Chu JX, Wang M, Yang TY, et al. Experimental study on minimal residual leukemia. J Chin Hematol 1991;12(8):394–397.

Gale RP, Ben R. Autotransplants in leukemia: current state, future progress. Leukemia Res 1991; 15(9):781–786.

Teng Y. Effect of Chinese herbs on transplanting lymphocyte leukemia in mice. Shanghai J TCM 1992; (3) :47–48.

Zhang DZ. Enhancing efficacy and abate toxicity effect of Chinese drugs in treating tumor. Chin J Integr Med 1992; 12(3): 135.

Luo HS, Luo DH. Immune Chinese drugs—immunologic pharmacology and clinics of Chinese drugs. Beijing: Combined Publishing House of Beijing Medical University and PUMC. 1998: 40–48.

Gale RP, Bulturini T. Is transplantation in first remission AML more effective than in advanced leukemia? Leukemia Res 1989; 13(12): 1035–1039.

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