Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells

Lu-lu Ge; Wei Zhang; Yun Dai; Yan Zang; Chun-jie Huang

doi:10.1007/BF02934376

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Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells

OriginalPaper | Updated：2021-08-27

- Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells
- Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells
- 中国结合医学杂志（英文版） 2001年7卷第4期页码：293-296
- Affiliations：
  
  The First Military Medical University,Guangzhou
- Author bio：
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- DOI：10.1007/BF02934376
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- 纸质出版日期：2001，
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Ge, Ll., Zhang, W., Dai, Y. et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells., CJIM 7, 293–296 (2001). https://doi.org/10.1007/BF02934376

Lu-lu Ge, Wei Zhang, Yun Dai, et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells[J]. Chinese Journal of Integrative Medicine, 2001,7(4):293-296.
Ge, Ll., Zhang, W., Dai, Y. et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells., CJIM 7, 293–296 (2001). https://doi.org/10.1007/BF02934376 DOI：

Lu-lu Ge, Wei Zhang, Yun Dai, et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells[J]. Chinese Journal of Integrative Medicine, 2001,7(4):293-296. DOI： 10.1007/BF02934376.

摘要

To observe the effects of essential garlic oil (EGO) on vascular cell adhesive molecule-1 (VCAM-1) expression of endothelial cells and monocyte-endothelial cell adhesion rate induced by interleukin-lα(IL-lα). Human umbilical vein endothelial cells (HUVEC) were isolated by trypsin digestion method and co-cultured with IL-1α or EGO + IL-lα in the absence or presence of U937 monocyte. Monocyte-endothelial cell adhesion rate was examined with reverted microscope. VCAM-1 expression of endothelial cells was measured by ACAS 570 confocal microscope

and the data were presented as mean fluorescent intensity. EGO significantly inhibited IL-lα-induced endothelial expression of VCAM-1

and thus markedly decreased monocyte-endothelial cell adhesion rate. EGO has the effect on antagonizing adhesion of monocyte and vascular endothelial cell

which might be due to its inhibition on adhesive molecular expression on the surface of endothelial cells.

Abstract

and the data were presented as mean fluorescent intensity. EGO significantly inhibited IL-lα-induced endothelial expression of VCAM-1

and thus markedly decreased monocyte-endothelial cell adhesion rate. EGO has the effect on antagonizing adhesion of monocyte and vascular endothelial cell

which might be due to its inhibition on adhesive molecular expression on the surface of endothelial cells.

关键词

essential garlic oilendothelial cellsmonocytesvascular cell adhesive molecule-1interleukin-lα

Keywords

essential garlic oilendothelial cellsmonocytesvascular cell adhesive molecule-1interleukin-lα

references

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