To observe the effect of Shenbing Mixture (SBM) of the recurrence of simple nephrotic syndrome of children. Sixty-eight patients treated with SBM combined with prednisone were observed and compared with those in the control group treated with prednisone alone. The 1-year recurrence rate of the treated group was 14. 3%

which was obviously lower than that in the control group (59.3%

P<0. 01). Serum level of Cortisol

IgG

IgA

CD3

CD4

CD4/ CD8 ratio and rosette formation rate of RBC-C3b in patients before treatment were all significantly lower than normal range. After being treated with SBM combined with prednisone

the above-mentioned indexes were all improved significantly and close to normal. SBM had obvious effect in reducing recurrence of nephrotic syndrome in children

the mechanism is closely related to multiple pathways

including adjustment of T-lym-phocyte dysfunction

improving humoral immunity and RBC immune function

and promoting the recovery of adrenal cortex function.