Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris

Yan Lei; Ke-Ji Chen; Jian-Gang Liu; Yong-Gang Xu

doi:10.1007/BF02934402

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Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris

OriginalPaper | Updated：2021-08-27

- Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris
- Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris
- 中国结合医学杂志（英文版） 2002年8卷第4期页码：267-270
- Affiliations：
  
  Xiyuan Hospital, China Academy of TCM,Beijing
- Author bio：
- Funds：
  
  This is a focal project funded by National Natural Science Foundation of China(No. 39630360)
- DOI：10.1007/BF02934402
  中图分类号：
- 纸质出版日期：2002，
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Lei, Y., Chen, KJ., Liu, JG. et al. Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris., CJIM 8, 267–270 (2002). https://doi.org/10.1007/BF02934402

Yan Lei, Ke-Ji Chen, Jian-Gang Liu, et al. Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris[J]. Chinese Journal of Integrative Medicine, 2002,8(4):267-270.
Lei, Y., Chen, KJ., Liu, JG. et al. Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris., CJIM 8, 267–270 (2002). https://doi.org/10.1007/BF02934402 DOI：

Yan Lei, Ke-Ji Chen, Jian-Gang Liu, et al. Effect of Xuefu Zhuyu pill on platelet activating factor expression in patients with unstable angina pectoris[J]. Chinese Journal of Integrative Medicine, 2002,8(4):267-270. DOI： 10.1007/BF02934402.

摘要

To explore the significance of platelet activation (PA) in patients with unstable angina pectoris (UA) and the effect of Xuefu Zhuyu pill (XZP

a Chinese composite recipe) on it

by way of determining platelet membrane glycoprotein CD62P

CD41/CD45 expressions in whole blood of healthy persons and UA patients. XZP was given orally to 45 UA patients for 2 weeks. Their expressions of CD62P and CD41/CD45 in peripheral blood were determined before and after treatment by whole blood flow cytometry with special marked antibody

and compared with those in 10 healthy persons of the same age as a normal control group. Amount of expressions of CD62P and CD41/CD45 (FC%) in UA patients before treatment were 24. 22±7. 92 and 25. 89±8.10 respectively

all higher than those in the control group (P<0.01 andP<0.05). After treatment

CD62P lowered to 20. 42±8. 01

significantly different from that of before treatment(P<0.05)

and CD41/CD45 also showed a trend of lowering (P> 0.05) . Platelet adhesion rate reduced significantly (P<0.05) at the same time

as compared with that of before treatment. Highly platelet activated state exists in UA patients. XZP could inhibit platelet membrane glycoprotein CD62P and CD41/CD45 expressions

which might be the molecular mechanism of it in antagonizing PA.

Abstract

To explore the significance of platelet activation (PA) in patients with unstable angina pectoris (UA) and the effect of Xuefu Zhuyu pill (XZP

a Chinese composite recipe) on it

by way of determining platelet membrane glycoprotein CD62P

all higher than those in the control group (P<0.01 andP<0.05). After treatment

CD62P lowered to 20. 42±8. 01

significantly different from that of before treatment(P<0.05)

and CD41/CD45 also showed a trend of lowering (P> 0.05) . Platelet adhesion rate reduced significantly (P<0.05) at the same time

as compared with that of before treatment. Highly platelet activated state exists in UA patients. XZP could inhibit platelet membrane glycoprotein CD62P and CD41/CD45 expressions

which might be the molecular mechanism of it in antagonizing PA.

关键词

Xuefu Zhuyu Pillunstable angina pectorisplatelet activationwhole blood flow cytometryClinical Study

Keywords

Xuefu Zhuyu Pillunstable angina pectorisplatelet activationwhole blood flow cytometryClinical Study

references

Branch of Cardio-vascular Diseases, Chinese Association of Medicine, Editorial Committee of Chinese Journal of Cardiology. Suggestion on diagnosis and treatment of unstable angina pectoris. Chin J Cardiol 2000;28(6): 409–412.

Fitzgerald DJ, Louis R, Catella F, et al. Platelet activated in unstable coronary disease. N Engl J Med 1986; 315: 983–998.

Ross R. The pathogenesis of atherosclerosis: a perspective for 1990s. Nature 1993; 362: 801–809.

Abrams CS, Ellison N, Budzynski AZ. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood 1990;75: 128–138.

Lin Y, Wang Z. Mutual effect of platelet and leukocyte in rats with acute myocardial infarction. Basic Medical Sciences and Clinics 1997; 17(5): 56–59.

Skinner MP, Lucas ML, Burns G. F., et al. GMP-140 binding to neutrophils is inhibited by sulfated glycans. J Biol Chem 1991;266(9): 5371–5374.

Murakamin T, Komiyama Y, Masuda M, et al. Flow cytometric analysis of platelet activation markers CD62P and CD63 in patients with coronary artery disease. Eur J Clin Invest 1996: 26(11): 996–1003.

Zhu JJ, Gao HQ, Zhang ZM. Clinical study on platelet activation manner in patients with unstable angina pectoris. Journal of Shandong Medical University 2001; 39(1): 16–20.

Li MM. Determination of platelet function by flow cytom-eter and its clinical application. Chin J Med Lab Sci 1999; 22(3): 182–184.

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