Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma

Xin-Sheng Fan; Zhi-Xiang Zhou; Jing Jiang; Jing-Hua Yu; Ning Shang; Liu-Qing Di

doi:10.1007/BF02934404

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Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma

OriginalPaper | Updated：2021-08-27

- Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma
- Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma
- 中国结合医学杂志（英文版） 2002年8卷第4期页码：275-278
- Affiliations：
  
  1. Nanjing University of Traditional Chinese Medicine,Nanjing
  2. The First People’s Hospital of Yancheng,Jiangsu
  3. The Hospital of PL A,Nanjing,454
- Author bio：
- Funds：
  
  A basic application item of Sciences and Technology Department of Jiangsu Province (BJ99074)
- DOI：10.1007/BF02934404
  中图分类号：
- 纸质出版日期：2002，
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Fan, XS., Zhou, ZX., Jiang, J. et al. Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma., CJIM 8, 275–278 (2002). https://doi.org/10.1007/BF02934404

Xin-Sheng Fan, Zhi-Xiang Zhou, Jing Jiang, et al. Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma[J]. Chinese Journal of Integrative Medicine, 2002,8(4):275-278.
Fan, XS., Zhou, ZX., Jiang, J. et al. Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma., CJIM 8, 275–278 (2002). https://doi.org/10.1007/BF02934404 DOI：

Xin-Sheng Fan, Zhi-Xiang Zhou, Jing Jiang, et al. Effects of composite xinyi aerosol on asthma related cytokines in senm and sputum of patients with bronchial asthma[J]. Chinese Journal of Integrative Medicine, 2002,8(4):275-278. DOI： 10.1007/BF02934404.

摘要

To observe the therapeutic effect of composite Xinyi aerosol

XYA) in treating asthma and its influence on asthma related cytokines in serum and sputum of patients with mild or moderate bronchial asthma. Sixty patients were divided randomly into the treated group and the control group

30 in each group. They were treated with XYA and Salbutamol aerosol (SA) respectively by spray inhalation once a day for seven days as one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α)

interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunosorbent assay (ELISA). Levels of TNF-α

IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed. In the treated group

6 patients had the asthma clinically controlled after treatment

12 were markedly alleviated

9 alleviated and 3 remained unchanged

while in the control group

the respective numbers were 4

15 and 5. The controlled-markedly effective rate of XYA was 60. 0%

which was significantly better than that of SA (33. 3%

P<0.05). The one second forced expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improved significantly and the levels of TNF-α

IL-2R and IL-8 in serum decreased noticeably in both groups after treatment (P<0.05 orP<0. 01)

but the improvement in the treated group was more significant as compared with those in the control group (P<0.05) . The levels of TNF-α

IL-2R and IL-8 in sputum considerably lowered also after XYA treatment (P<0.01). XYA could regulate the related cytokines in patients with mild or moderate bronchial asthma

and reduce the releasing of inflammatory factors

which is consistent with the improvement of lung functions

so as to ease the airway inflammation chiefly exhibited as cell infiltration in bronchi.

Abstract

To observe the therapeutic effect of composite Xinyi aerosol

interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunosorbent assay (ELISA). Levels of TNF-α

IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed. In the treated group

6 patients had the asthma clinically controlled after treatment

12 were markedly alleviated

9 alleviated and 3 remained unchanged

while in the control group

the respective numbers were 4

15 and 5. The controlled-markedly effective rate of XYA was 60. 0%

which was significantly better than that of SA (33. 3%

P<0.05). The one second forced expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improved significantly and the levels of TNF-α

IL-2R and IL-8 in serum decreased noticeably in both groups after treatment (P<0.05 orP<0. 01)

but the improvement in the treated group was more significant as compared with those in the control group (P<0.05) . The levels of TNF-α

IL-2R and IL-8 in sputum considerably lowered also after XYA treatment (P<0.01). XYA could regulate the related cytokines in patients with mild or moderate bronchial asthma

and reduce the releasing of inflammatory factors

which is consistent with the improvement of lung functions

so as to ease the airway inflammation chiefly exhibited as cell infiltration in bronchi.

关键词

Asthmatumor necrosis factor αinterleukin-2 receptorinterleukin-8composite Xinyi aerosol

Keywords

Asthmatumor necrosis factor αinterleukin-2 receptorinterleukin-8composite Xinyi aerosol

references

Di LQ, Fan XS, Fan BT. Research on preparation and quality control of aerosol for anti-asthma. Journal of Nanjing University of TCM 1999; 15(2): 88–90.

Xu HQ, Fang TH, Jin SHE, et al. Pharmacological research on anti-asthmatic effect of Xinyi aerosol. Journal of Nanjing University of TCM 1998; 14(6): 348–351.

Fan XS, Zhou ZX, Jiang J, et al. Clinic effect of Xinyi aerosol for treatment of asthma and its influence on level of IL-8 in serum and sputum of patients with bronchial asthma. Chin J Med & Pharmacol 2001; 16(2): 38–41.

Branch of Internal Medicine, Chinese Association of TCM. Standard of diagnosis and effect evaluation of asthma (revised edition). Chin J Med & Pharmacol 1988;3(3): 67.

Ministry of Health. Guidline of Clinical Research on Chinese New Drugs. 1st vol. 1993: 4.

Directory in prevention and treatment of bronchial asthma. Chin J Tuberc & Respir Dis 1997; 20(5): 26.

Wang QF. Immunology and Immunological Experimental Techniques. Beijing: Publishing Company of Chinese Medical Science and Technology, 1995: 85–87.

Deng HJ, Sun B, Zhan XL. Clinic significance of cytokines and eosinophilcationic protein concentrations in sputum of asthmatic patients. Chin J Tuberc & Respir Dis 1998;21(2): 108–110.

Piacentini CL, Kaliner MA. The potential roles of leukotrienes in bronchial asthma. Am Rev Respir Dis 1991; 143: 996–999.

Tillie-Leblond I, Pugin J, Marquette CH, et al. Balance between pro-inflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am J Respir and Crit Care Med 1999; 159(2): 487–494.

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