To observe the short-term effect and follow-up of integrative medicine in treating patients with hepatolenticular degeneration (HLD). Methods: The 198 patients with HLD were treated by strengthened decopper therapy with sodium dimercaptosulphonate by intravenous dripping combined with oral intake of Gandou tablet and zinc gluconate during their hospitalization period. After discharge

the maintaining therapy given to them was dimercaptosuccinic acid and penicillamine alternatively combined with Gandou Tablet and zinc gluconate orally. Patients were followed-up for 6 months to 24 years. By the end of therapeutic course in hospital

the clinically cured

markedly improved and improved cases were 22 (11.11%)

15 (7.58%) and 131(66.16%) respectively

the cure rate+ markedly effective rate being 18. 69% and the total effective rate 84.85%. The markedly effective rate and the total effective rate were increased significantly at the 6 months follow-up

while in the over 6 months to 24 years follow-up period the cure + markedly effective rate increased

and ineffective and worsened rate also increased

only improved rate lowered were shown. Most HLD patients would acquire long-term survival and better quality of life if they insist on long-term decopper therapy. Condition would be deteriorated

even death often occur in those who cannot insist the treatment or in severe cases of advanced stage.