Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats

Xiu-zhen Lin; Yao Zheng; De-lu Ma; Wen-li Xie; Shan Zhao; Xian-zhong Wu

doi:10.1007/BF02934413

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Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats

OriginalPaper | Updated：2021-08-27

- Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats
- Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats
- 中国结合医学杂志（英文版） 2002年8卷第4期页码：299-301
- Affiliations：
  
  Department of Pharmacology, Tianjin Medical University,Tianjin,China
- Author bio：
- Funds：
- DOI：10.1007/BF02934413
  中图分类号：
- 纸质出版日期：2002，
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Lin, Xz., Zheng, Y., Ma, Dl. et al. Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats., CJIM 8, 299 (2002). https://doi.org/10.1007/BF02934413

Xiu-zhen Lin, Yao Zheng, De-lu Ma, et al. Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats[J]. Chinese Journal of Integrative Medicine, 2002,8(4):299-301.
Lin, Xz., Zheng, Y., Ma, Dl. et al. Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats., CJIM 8, 299 (2002). https://doi.org/10.1007/BF02934413 DOI：

Xiu-zhen Lin, Yao Zheng, De-lu Ma, et al. Effect of dachengqi granules on level of endotoxin in enterogenous endotoxemia in rats[J]. Chinese Journal of Integrative Medicine, 2002,8(4):299-301. DOI： 10.1007/BF02934413.

摘要

To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia. Enterogenous endotoxemia model of rats was made by peritoneal injection of E. coli. In the treated groups

the rats were treated with different doses of DCQG

cefaclor and DCQG plus cefaclor respectively

starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma

urine and stool were determined and compared. Except for the cefaclor group

the plasma and urine endotoxin levels in the treated groups were lower significantly (P<0.05)

while the endotoxin level in stool was obviously higher than that in the untreated model group. DCQG has the intestinal barrier protective effect including anti-bacteria

anti-inflammation and clearing endotoxin.

Abstract

the rats were treated with different doses of DCQG

cefaclor and DCQG plus cefaclor respectively

starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma

urine and stool were determined and compared. Except for the cefaclor group

the plasma and urine endotoxin levels in the treated groups were lower significantly (P<0.05)

while the endotoxin level in stool was obviously higher than that in the untreated model group. DCQG has the intestinal barrier protective effect including anti-bacteria

anti-inflammation and clearing endotoxin.

关键词

Dachengqi Granuleenterogenous endotoxemiaendotoxinrat

Keywords

Dachengqi Granuleenterogenous endotoxemiaendotoxinrat

references

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Read LL, Martin M, Manglian R, et al. Bacteria translocation following abdominal trauma in human. Circ Shock 1994;42: 1.

Redl G, Schlag G, Bahrami S, et al. Animal models as the basis of pharmacological intervention in trauma and sepsis patients. World J Surg 1996;20: 487–492.

Woodsman GE, Fabian TC, Croce MA, et al. Acute ethanol intoxication and endotoxemia after trauma. J Trauma 1996;41(1): 61.

Liu J, Zhao Q, Zhou WL, et al. Effect of Daichengqi Decoction on translocation of enterogenous endotoxin in peritonitis rats. Chin J Surg Integr Tradit &. West Med 1997: 3(6):374.

Zhang YX. Pay attention to the rational application of antibiotics in clinical surgery.Chin J Practical Surgery 1998;18(10): 582–583.

Lin XZ. The protective effects of the purgative action of Dachengqi Decoction on intestinal barrier function. In Zhou JH, Wan JH ed.Advances of Pharmacological and Clinical Researches of Traditional Chinese Medicine. Beijing:Military Medical Science Publishing House. 1995;254–261.

Lin XZ and Huang B. Effect of Dachengqi Decoction on serum lysozyme activity in rabbits. Chin J of Surgery of Integrated Traditional and Western Medicine 1999: 5(2):81–82.

Guo CH, Zheng HS and Lin XZ. Effects of Dachengqi Decoction on peroxidation injury induced by endotoxin.Pharmacology and Clinics of Chinese Meteria Medica 1998,14(2): 7–8.

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