To prove the effect of Kesuning Granule (KSNG) in treating chronic bronchitis in exacerbation (Phlegm-Heat syndrome) and objectively evaluate its safety. The double-blinded

double-dummy and randomized controlled method was adopted to observe 120 patients

who were divided into the treated group (n—60

treated with KSNG 8g

three times a day) and the control group (n=60

treated with Jinbei Tankeqing Granule (JBTKQ) 7g

three times a day). The therapeutic course for both groups was 6 days. In the treated group

the markedly effective rate was 58. 33% and effective rate was 93.33%

while in the control group

they were 51.67% and 91. 67% respectively

no significant difference was found between the two groups. For therapeutic effects on TCM syndromes

the markedly effective rate and effective rate in the treated group was 68. 33% and 93.33% respectively and in the control group

66.67% and 90.00% respectively

also showed insignificant difference. The effect initiative time was earlier in the treated group than that in the control group significantly (P<0.05). No adverse effect was found in the observation. KSNG shows a definite clinical effect with no obvious toxic-adverse effects.