Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration

Hu Wen-Bin; Yang Ren-Min; Ren Ming-shan; Yang Guang-e

doi:10.1007/BF02934609

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Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration

OriginalPaper | Updated：2021-08-27

- Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration
- Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration
- 中国结合医学杂志（英文版） 2002年8卷第1期页码：7-10
- Affiliations：
  
  Institute of Neurology, Affiliated Hospital, Anhui Colledge of Traditional Chinese Medicine,Anhui Province,Hefei
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundetion, No.39570878
- DOI：10.1007/BF02934609
  中图分类号：
- 纸质出版日期：2002，
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Hu, WB., Yang, RM., Ren, Ms. et al. Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration., CJIM 8, 7–10 (2002). https://doi.org/10.1007/BF02934609

Hu Wen-Bin, Yang Ren-Min, Ren Ming-shan, et al. Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration[J]. Chinese Journal of Integrative Medicine, 2002,8(1):7-10.
Hu, WB., Yang, RM., Ren, Ms. et al. Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration., CJIM 8, 7–10 (2002). https://doi.org/10.1007/BF02934609 DOI：

Hu Wen-Bin, Yang Ren-Min, Ren Ming-shan, et al. Observation of the clinical therapeutic effect of gandou tablet i on hepatolenticular degeneration[J]. Chinese Journal of Integrative Medicine, 2002,8(1):7-10. DOI： 10.1007/BF02934609.

摘要

Objective: To investigate the therapeutic efficacy of Gandou Tablet I in treating hepatolenticular degeneration (HLD) and its effect on urinary trace element in 24 hours. Thirtyfour patients with HLD took Gandou Tablet I for 4 weeks

their changes of symptoms

signs and daily life pattern were observed closely

and the levels of urinary trace element in 24 hours before the therapy and every week after initiation of treatment were measured. The total effective rate reached 70.59%

with markedly effective rate being 8.82%. The therapeutic effect was much better in the child and mild patients. After treatment

the daily urinary copper output was obviously increased every week compared with that before (P< 0.01). Although it was highly negative linear correlated with the duration of treatment (γ= -0.96

P< 0.05)

it has insignificant difference between any two weekly excretion of urinary copper per 24 hours after treatment (P<0.05). So its effect on urinary copper excretion was not decreased. Gandou Tablet I could increase the output of urinary copper

hence it was effective in treating HLD without apparent toxic or side reaction.

Abstract

their changes of symptoms

signs and daily life pattern were observed closely

and the levels of urinary trace element in 24 hours before the therapy and every week after initiation of treatment were measured. The total effective rate reached 70.59%

with markedly effective rate being 8.82%. The therapeutic effect was much better in the child and mild patients. After treatment

the daily urinary copper output was obviously increased every week compared with that before (P< 0.01). Although it was highly negative linear correlated with the duration of treatment (γ= -0.96

P< 0.05)

hence it was effective in treating HLD without apparent toxic or side reaction.

关键词

Hepatolenticular DegenerationGandou Tablet Iurinary trace element

Keywords

Hepatolenticular DegenerationGandou Tablet Iurinary trace element

references

Yang Rm, Bao Yc, Yang Xt, et al. Study on the excretion of copper in 37 cases of HLD-patients treated by HLD-decoction. Chin J Integr Trad West Med 1984;4(7): 462–464.

Yang Rm edited. Hepatolenticular degeneration. Hefei: Science and Technology Publishing House of Anhui, 1995: 167,184,201,255.

Goldstein NP. Treatment of Wilson’s disease with D-penicillamine. Neurol 1962; 12: 231.

Ren Ms, Yang Rm. The therapeutic effect of DMSA on HLD and its effect on trace elements in bile, etc. Chin J Nervous Mental Dis 1990; 16(6):326–328.

Yang Rm, Bao Yc, Jiang Tz, et al. Research for side effect of PCA. J New Drug Clin Remedies 1996; (5): 91–94.

Jiangsu University of Chinese Medicine edited. Chinese medicine dictionary. Shanghai: Science and Technology Publishing House of Shanghai, 1986: 102,1735.

Yang Rm, Bao Yc, Cai Yl, et al. Effect on the excretion of urinary copper and other trace elements in 60 cases of HLD-patients who have taken zinc sulfate orally. National Med J Chin 1986; 66(4): 211–214.

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