Objective: To investigate a new method of combined laparoscopy with Chinese herbal medicine (CHM) in treating endometrial ovarian cyst. One hundred and fifty-two patients with endometrial ovarian cyst were randomly divided into 3 groups treated with three therapies: combined laparoscopy with CHM (combination group)

CHM (TCM group) and danazol (WM group). To compare the clinical efficacy and sideeffects shown by the three groups and to elucidate the therapeutic mechanism by detecting the serum CA125 reproductive endocrine hormone

plasma prostaglandin F2a prostaglandin E2 etc. The shrinking rate

disappearance rate of the cysts and markedly effective rate in the combination group were obviously higher than those in the TCM group and WM group (P< 0.05

P<0.01). The pregnancy rate of combination group was also higher than that of the WM group (P<0.05). Few side-effects constituted the most prominent advantage for the combination group and TCM group. After treatment

the plasma prostaglandin F1a lowered remarkably

serum progesterone increased and CA125 reduced obviously (P<0.01

P<0.05). The laparoscopy and CHM combination therapy is a new method in treating endometrial ovarian cyst which has significant efficacy

minimal adverse effect and maximal preservation of reproductive function.