Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine

Rong-Xi Yu; Yu-Hong Zhou; Ning-Xi Zhu; Jian-Ping Shen; Zhi-Ping Hu; Xiu-Su Luo; Sheng-Yun Lin; Yi-Ping Shen; un-Fa Chen; Jie Sun

doi:10.1007/BF02934614

Your Location：

Home >

Browse articles >

Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine

OriginalPaper | Updated：2021-08-27

- Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine
- Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine
- 中国结合医学杂志（英文版） 2002年8卷第1期页码：27-32
- Affiliations：
  
  Zhejiang Provincial Hospital of TCM,Hangzhou
- Author bio：
- Funds：
  
  This work is supported by the Zhejiang Provincial Administration of TCM
- DOI：10.1007/BF02934614
  中图分类号：
- 纸质出版日期：2002，
Scan for full text
Yu, RX., Zhou, YH., Zhu, NX. et al. Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine., CJIM 8, 27–32 (2002). https://doi.org/10.1007/BF02934614

Rong-Xi Yu, Yu-Hong Zhou, Ning-Xi Zhu, et al. Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine[J]. Chinese Journal of Integrative Medicine, 2002,8(1):27-32.
Yu, RX., Zhou, YH., Zhu, NX. et al. Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine., CJIM 8, 27–32 (2002). https://doi.org/10.1007/BF02934614 DOI：

Rong-Xi Yu, Yu-Hong Zhou, Ning-Xi Zhu, et al. Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine[J]. Chinese Journal of Integrative Medicine, 2002,8(1):27-32. DOI： 10.1007/BF02934614.

摘要

To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese erbal medicine in treating malignant hematopathy. Allo-bone marrow transplantation (allo-BMT) or allo-peripheral blood stem cell transplantation (allo-PBSCT)

with conditioning regimen of60Co total body irradiation + Cyclophosphamide (TBI+ Cy) or busulfan + cyclophosphamide (Bu + Cy)

was used to treat 4 cases of chronic granulocytic leukemia (CGL

3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT

with conditioning regimen of myleran + cytosino arabinoside + cyclophosphamide (MAC) or MAC+ VP16

was used to treat 7 cases of hematopathy

including 5 cases of ANLL (3 of CR1 and 2 of CR2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. All patients were successfully engrafted. Within the median follow-up period of 18 (4-70) months

1 patient (8.3%) died a transplantation-related death

3 (25.0%) relapsed and 8 (66.7%) survived free of original disease. CR1 stage of acute leukemia could reduce the relapse rate

when there was no matched bone marow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain role in promoting recovery of hematopoietic function.

Abstract

with conditioning regimen of60Co total body irradiation + Cyclophosphamide (TBI+ Cy) or busulfan + cyclophosphamide (Bu + Cy)

was used to treat 4 cases of chronic granulocytic leukemia (CGL

3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT

with conditioning regimen of myleran + cytosino arabinoside + cyclophosphamide (MAC) or MAC+ VP16

was used to treat 7 cases of hematopathy

1 patient (8.3%) died a transplantation-related death

3 (25.0%) relapsed and 8 (66.7%) survived free of original disease. CR1 stage of acute leukemia could reduce the relapse rate

关键词

Leukemialymphomahematopoietic stem cells transplantationChinese Herbal Medicine

Keywords

Leukemialymphomahematopoietic stem cells transplantationChinese Herbal Medicine

references

Zittoun RA, Mandelli F, Willemze R, et al. Autologous or allogeneic bone marrow transplantation compared with intensive chemotherpy in acute myelogenous leukemia. N Engl J Med 1995; 332(4): 217–223.

Koc H, Gurman G, Arslan D, et al. Allogenic peripheral blood stem cell transplantation: Is there an increased risk of graft vs host disease in leukemic patients? J Chemother 1997;9(5):371–376.

Miflin G, Rusell NH, Hutenison RM, et al. Allogenic peripheral blood stem cell transplantation for hematological malignancies—an analysis of kinetics of engraftment and GVHD risk. BMT 1997;19(1):9–13.

Stone K, Gooley T, Siadak M, et al. Allogenic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft vs host disease. Blood 1997;90: 4705–4718.

Mehta J, Powles R, Singhal S, et al. Autologous bone marrow transplantation for acute myeloid leukemia in first remission: Identification of modifiable prognostic factors. BMT 1995; 16:499–506.

Han Mz, Feng Sz, Li Cw. Efficacious analysis of autologous BMT in treating 73 cases of acute leukemia. Chin J Hemat 1998; 19 (8): 422–424.

Yeager AM, Vogelsang GB, Jones RJ, et al. Induction of cutaneous graft versus host disease by administration of cyclosporine to patients undergoing autologous bone marrow transplantation for acute myeloid leukemia. Blood 1992; 79 (ll):3031–3035.

Han R. Chemical prevention and pharmaceutical treatment of tumors. Beijing: Beijing Medical University-PUMC Union Press, 1991:719–729.

FULL TEXT LINK

More>

浏览量

397

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Arsenic disulfide induced apoptosis and concurrently promoted erythroid differentiation in cytokine-dependent myelodysplastic syndrome-progressed leukemia cell line F-36p with complex karyotype including monosomy 7

Development is a high level inheritance for China Time-honored Brand products

Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome

Tounongsan (透脓散) extract induces apoptosis in cultured Raji cells

Chinese herbal medicine in the treatment of nonalcoholic fatty liver disease