Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients

Bao-Jing Lu; Ye-Zhi Rong; Mei-Hua Zhao; Guo-Fang Huang; Xiang-Yang Zhu; Jin-Wen Yang

doi:10.1007/BF02934685

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Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients

OriginalPaper | Updated：2021-08-27

- Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients
- Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients
- 中国结合医学杂志（英文版） 1996年2卷第4期页码：249-251
- Affiliations：
  
  Department of Cardiology, Xinhua Hospital, Shanghai Second Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934685
  中图分类号：
- 纸质出版日期：1996，
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Lu, BJ., Rong, YZ., Zhao, MH. et al. Effect of Shengmaisan () on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients., CJIM 2, 249–251 (1996). https://doi.org/10.1007/BF02934685

Bao-Jing Lu, Ye-Zhi Rong, Mei-Hua Zhao, et al. Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients[J]. Chinese Journal of Integrative Medicine, 1996,2(4):249-251.
Lu, BJ., Rong, YZ., Zhao, MH. et al. Effect of Shengmaisan () on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients., CJIM 2, 249–251 (1996). https://doi.org/10.1007/BF02934685 DOI：

Bao-Jing Lu, Ye-Zhi Rong, Mei-Hua Zhao, et al. Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients[J]. Chinese Journal of Integrative Medicine, 1996,2(4):249-251. DOI： 10.1007/BF02934685.

摘要

The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients

30 angina pectoris and 68 acute myocardial infarction (AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood decreased and the content of malondialdehyde (MDA) in plasma increased in CHD patients in comparison with the healthy controls (P<0.001). When SMS was orally administered in 38 AMI patients

both SOD and GSH-Px activities were increased and the level of MDA decreased (P<0. 05)

and these changes were even more significant when SMS was further ingested for another two weeks (P<0. 001). AT the same time

it was found that the changes of SOD

GSH-Px and MDA in the control group (30 AMI patients not taking SMS) were not significantly different (P>0. 05). It could be assumed that the pathogenesis of CHD is associated with free radical (FR) triggering a chain reaction of the lipid peroxidation

and that SMS is acting as an effective free radical scavenger

which would ameliorate the lipid peroxidation damage. Thus

SMS could be administered in the prevention and the treatment of CHD.

Abstract

The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients

both SOD and GSH-Px activities were increased and the level of MDA decreased (P<0. 05)

and these changes were even more significant when SMS was further ingested for another two weeks (P<0. 001). AT the same time

it was found that the changes of SOD

and that SMS is acting as an effective free radical scavenger

which would ameliorate the lipid peroxidation damage. Thus

SMS could be administered in the prevention and the treatment of CHD.

关键词

Shengmaisanacute myocardial infarctionfree radicallipid peroxidation

Keywords

Shengmaisanacute myocardial infarctionfree radicallipid peroxidation

references

Steinberg D, Parthasarathy S, Carew TE, et al. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Eng J Med 1989; 320:915.

Steinberg D, Witztum JL. Lipoproteins and atherosclerosis. JAMA 1990; 264:3047.

1990; 18:248.

Chen Yuan, Zhou Mei, Liu Yi-Li, et al. Lipoperoxidative damage in patients with coronary heart disease. Med Sci Res 1988; 16:1059.

1988; 68:313.

Misra HP, Fridovich I. Superoxide dismutase: a photochemical augmentation assay. Arch Biochem and Biophys 1977; 181:308.

Hafeman DG, Sunde RA, Hoekstra WG. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutra 1974; 104:580.

1987; 1: 24.

1992; 31:113.

1988; 8 (I):101.

Hori M, Gotoh K, Kitakaze M, et al. Role of oxygen-derived free radicals in myocardial edema and ischemia in coronary microvascular embolization. Circulation 1991; 84:828.

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