Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models

Cong-rong Gao; Jia-qing Zhang; Qing-ling Huang

doi:10.1007/BF02934837

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Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models

OriginalPaper | Updated：2021-08-27

- Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models
- Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models
- 中国结合医学杂志（英文版） 1997年3卷第4期页码：282-285
- Affiliations：
  
  Department of Endocrinology, Changhai Hospital,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934837
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- 纸质出版日期：1997，
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Gao, Cr., Zhang, Jq. & Huang, Ql. Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models., CJIM 3, 282–285 (1997). https://doi.org/10.1007/BF02934837

Cong-rong Gao, Jia-qing Zhang, Qing-ling Huang. Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models[J]. Chinese Journal of Integrative Medicine, 1997,3(4):282-285.
Gao, Cr., Zhang, Jq. & Huang, Ql. Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models., CJIM 3, 282–285 (1997). https://doi.org/10.1007/BF02934837 DOI：

Cong-rong Gao, Jia-qing Zhang, Qing-ling Huang. Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models[J]. Chinese Journal of Integrative Medicine, 1997,3(4):282-285. DOI： 10.1007/BF02934837.

摘要

Objective: To observe the effects of berberine on insulin sensitivity in high-fat-fed rats.Methods: Before and after ingesting berberine

glucose insulin tolerance test was used to measure the insulin sensitivity

and to determine the fasting blood glucose

insulin

blood lipid and muscle triglyceride content.Results: Compared with normally fed rats

high-fat-fed rats had their insulin sensitivity lowered (K value 5.02 ± 1.08 vs 8.72+0.91

P <0.005)

level of liver glycogen decreased and levels of fasting blood glucose

insulin

lipid and muscle triglyceride content raised. Berberine and metformin improved insulin resistance (K value 6.31 ± 0. 95 and 6.24 ± 0.65) and liver glycogen level in insulin resistant models

though they had no effect on blood glucose

insulin

lipid levels and muscle triglyceride depots.Conclusion: It is confirmed that berberine had similar effect in raising insulin sensitivity of high-fat-fed rats.

Abstract

Objective: To observe the effects of berberine on insulin sensitivity in high-fat-fed rats.Methods: Before and after ingesting berberine

glucose insulin tolerance test was used to measure the insulin sensitivity

and to determine the fasting blood glucose

insulin

blood lipid and muscle triglyceride content.Results: Compared with normally fed rats

high-fat-fed rats had their insulin sensitivity lowered (K value 5.02 ± 1.08 vs 8.72+0.91

P <0.005)

level of liver glycogen decreased and levels of fasting blood glucose

insulin

lipid and muscle triglyceride content raised. Berberine and metformin improved insulin resistance (K value 6.31 ± 0. 95 and 6.24 ± 0.65) and liver glycogen level in insulin resistant models

though they had no effect on blood glucose

insulin

lipid levels and muscle triglyceride depots.Conclusion: It is confirmed that berberine had similar effect in raising insulin sensitivity of high-fat-fed rats.

关键词

BerberineMetforminInsulin Sensitivityinsulin resistance

Keywords

BerberineMetforminInsulin Sensitivityinsulin resistance

references

Storlien LH, Oakes ND, Pan D, et al. Syndromes of insulin resistance in the rat: Inducement by diet and the amelioration with benfluorex. Diabetes 1993; 42: 457–460.

Kraegen EW, Clark PE, Jenkins AB, et al. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 1991; 40: 1397–1403.

1986; 21: 401–406.

Storlien LH, Jenkines AB, Chisholm DJ, et al. Influence of dietary fat composition on development of insulin resistance in rats. Diabetes 1991; 40: 280–289.

Levy J, Gavin III JR, Fausto A, et al. Impaired insulin action in rats with non-insulin-dependent diabetes. Diabetes 1984: 33: 901–906.

Van der Vies J. Two methods for the determination of glycogen in liver. Biochem J 1954; 57: 410–416.

Pagano G, Tagliaferro V, Carta Q, et al. Metformin reduces insulin requirement in type I (insulin dependent) diabetes. Diabetologia 1983; 24: 351–354.

Jackson RA, Hawa MI, Jaspan JB, et al. Mechanism of metformin action in non-insulin-dependent diabetes. Diabetes 1987: 36: 632–640.

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