Experimental study of protective effect of Qingkailing ( )on brain damage induced by glutamate)on brain damage induced by glutamate

Shao-Jie Yue; Pei-Lan Yu; Zi-Qiang Luo; Qjng-Shan Zeng; Yong-Guang Tao; Gan-Qiu Wu

doi:10.1007/BF02935016

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Experimental study of protective effect of Qingkailing ( )on brain damage induced by glutamate)on brain damage induced by glutamate

OriginalPaper | Updated：2021-08-27

- Experimental study of protective effect of Qingkailing ( )on brain damage induced by glutamate)on brain damage induced by glutamate
- Experimental study of protective effect of Qingkailing ( )on brain damage induced by glutamate)on brain damage induced by glutamate
- 中国结合医学杂志（英文版） 2001年7卷第2期页码：112-116
- Affiliations：
  
  Department of Pediatrics, Xiangya Hospital, Xiangya Medical College, Zhongnan University,Changsha
- Author bio：
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- DOI：10.1007/BF02935016
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- 纸质出版日期：2001，
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Yue, SJ., Yu, PL., Luo, ZQ. et al. Experimental study of protective effect of Qingkailing ()on brain damage induced by glutamate)on brain damage induced by glutamate., CJIM 7, 112–116 (2001). https://doi.org/10.1007/BF02935016

Shao-Jie Yue, Pei-Lan Yu, Zi-Qiang Luo, et al. Experimental study of protective effect of Qingkailing ( )on brain damage induced by glutamate)on brain damage induced by glutamate[J]. Chinese Journal of Integrative Medicine, 2001,7(2):112-116.
Yue, SJ., Yu, PL., Luo, ZQ. et al. Experimental study of protective effect of Qingkailing ()on brain damage induced by glutamate)on brain damage induced by glutamate., CJIM 7, 112–116 (2001). https://doi.org/10.1007/BF02935016 DOI：

Shao-Jie Yue, Pei-Lan Yu, Zi-Qiang Luo, et al. Experimental study of protective effect of Qingkailing ( )on brain damage induced by glutamate)on brain damage induced by glutamate[J]. Chinese Journal of Integrative Medicine, 2001,7(2):112-116. DOI： 10.1007/BF02935016.

摘要

Objective: To observe the effect of Qingkailing (QKL) on brain damage induced by glutamate

in order to seek for effective drugs for antagonizing neurotoxicity of glutamate.Methods:The number and morphological metrology of neurocytes in cerebral cortex and hippocampus were detected by MIAS-300 image analyser

electron microscope and immunohistochemical methods.Results: QKL could alleviate the glutamate induced accumulation of water and sodium in brain tissue

relieve the metrological and structural damage of cerebral cells in cortex and hippocampus

reduce the percentage of c-fos positive cell in brain.Conclusion: QKL could protect brain damage induced by glutamate

which might be related to the inhibition of QKL on the enhancement of cfos gene expression induced by glutamate.

Abstract

Objective: To observe the effect of Qingkailing (QKL) on brain damage induced by glutamate

electron microscope and immunohistochemical methods.Results: QKL could alleviate the glutamate induced accumulation of water and sodium in brain tissue

relieve the metrological and structural damage of cerebral cells in cortex and hippocampus

reduce the percentage of c-fos positive cell in brain.Conclusion: QKL could protect brain damage induced by glutamate

which might be related to the inhibition of QKL on the enhancement of cfos gene expression induced by glutamate.

关键词

cerebral damageGlutamateQingkailingelectron microscopec-fos genecell morphologicalmetrology

Keywords

cerebral damageGlutamateQingkailingelectron microscopec-fos genecell morphologicalmetrology

references

Yeu Sj. The excitatory neurotoxicity induced by glutamate and the damage of central nerve system. Foreign Medical Sciences 1994;21(4):205–208.

Yue Sj, Luo Zq, Yu Pl, et al. The protective effect of QKL on the excitatory neurotoxicity of glutamate. J Beijing Uni of TCM 1998;21(4):32–33.

Cheung Ns, Pascoe Cj, Giardina Sf, et al. Micromolar Lglutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurons. Neuropharmacology, 1998; (10)37:10–11, 1419-1429.

Yang Jh. Clinical application of QKL injection. Chinese Traditional Patent Medicine. 1994;16(12):20–21.

Jiang Yf, Zhu Lq, Li Kl, et al. The protective effect of Xingnao Jianshen capsule, Zhongfeng Naodeping, Qingkailing on hippocampal neurocytes in hemorrhagic apoplexy. J Beijing Uni of TCM 1996; 19(3):33–35.

Liu T, Meng Pj, Shen Fg, et al. The effect of Angong Niuhuang pills on glutamate neurotoxicity induced by cerebrospinal lactic dehydrogenase, lactic dehydrogenase of the cerebral tissue in rabbits. Jiangsu J TCM. 1987;6:33–35.

Tanaka S, Kiuchi Y, Numazawa S, et al. Changes in glutamate receptors, c-fos mRNA expression and activator protein-1 (AP-l)DNA binding activity in the brain of phenobarbital-dependent and -withdrawn rats. Brain Research 1997,756: 35–45.

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