Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice

Yan Jiao; Jie Wen; Xiao-hong Yu; De-shan Zhang

doi:10.1007/BF02935017

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Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice

OriginalPaper | Updated：2021-08-27

- Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice
- Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice
- 中国结合医学杂志（英文版） 2001年7卷第2期页码：117-120
- Affiliations：
  
  Department of Microbiology and Immunology, Heilongjiang University of TCM,Harbin
- Author bio：
- Funds：
- DOI：10.1007/BF02935017
  中图分类号：
- 纸质出版日期：2001，
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Jiao, Y., Wen, J., Yu, Xh. et al. Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice., CJIM 7, 117–120 (2001). https://doi.org/10.1007/BF02935017

Yan Jiao, Jie Wen, Xiao-hong Yu, et al. Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice[J]. Chinese Journal of Integrative Medicine, 2001,7(2):117-120.
Jiao, Y., Wen, J., Yu, Xh. et al. Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice., CJIM 7, 117–120 (2001). https://doi.org/10.1007/BF02935017 DOI：

Yan Jiao, Jie Wen, Xiao-hong Yu, et al. Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice[J]. Chinese Journal of Integrative Medicine, 2001,7(2):117-120. DOI： 10.1007/BF02935017.

摘要

Objective: To investigate the immune regulation of flavonoid of Astragalus membranaceus’s stem and leaf(FAM-sl).Methods: Changes of total T cell count and subsets in mice were determined by monoantibody assay before and after treatment with FAM-sl

and the lymphokine activated killer cell (LAK) activity was tested simultaneously by isotope label method.Results: FAM-sl could promote the proliferation of lymphocytes induced by ConA

raise the total T cell count and regulate the T cell subsets disturbance

and elevate the LAK activity induced by recombinant interleukin-2 (rIL-2).Conclusion: FAM-sl possesses effects of immune stimulation and immune regulation in treating immunosuppressive mice. This study provides experimental evidence for clinical application of FAM-sl.

Abstract

and the lymphokine activated killer cell (LAK) activity was tested simultaneously by isotope label method.Results: FAM-sl could promote the proliferation of lymphocytes induced by ConA

raise the total T cell count and regulate the T cell subsets disturbance

关键词

flavonoid in Astragalus membranaceus’s stem and leafT lymphocytelymphokine activated killer cellimmune regulation

Keywords

flavonoid in Astragalus membranaceus’s stem and leafT lymphocytelymphokine activated killer cellimmune regulation

references

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Ma Yl, Tian Zk, Yuan Cs. Studies on chemical ingredients in Astragalus membranaceus’s stem and leaf. J Shengyang Pharmacol College 1991; (2): 121–123,136.

Lu Sh, Zhu Yz, Wu Sj. Study on flavonoids in Astragalus membranaceus Bage van mongolicus stem and leaf. Chinese Traditional and Herbal Drugs 1990; 21 (6): 249–250,265.

Jiao Y, Wen J, Zhang Ds. Effects of flavonoid in Astragalus membranaceus’s stem and leaf on immune function in mice. Informations on TCM 1997;14(5):44.

Guan Hz, Kuang Yd, Qing Hl, et al. Comparison of 4 methods of assessing interleukin-2 (IL-2). Shanghai J Immunology 1986;6(5):298–301.

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Sheng Yq, Na Ah, Yang Zj, et al. Comparison of 12 species of Astragalus membranaceus on immune function in mice. Chinese J Immunology 1989;5(2): 119–121.

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