Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II

Shi Weibin; Zhang Hao; Du Ning; Wang Jiwei; Fu Shicong; Yang Jian; Qu Kefu; Li Guoheng

doi:10.1007/BF02935038

Your Location：

Home >

Browse articles >

Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II

OriginalPaper | Updated：2021-08-27

- Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II
- Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II
- 中国结合医学杂志（英文版） 1998年4卷第1期页码：9-11
- Affiliations：
  
  Ruijin Hospital, Shanghai Second Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02935038
  中图分类号：
- 纸质出版日期：1998，
Scan for full text
Weibin, S., Hao, Z., Ning, D. et al. Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II., CJIM 4, 9–11 (1998). https://doi.org/10.1007/BF02935038

Shi Weibin, Zhang Hao, Du Ning, et al. Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II[J]. Chinese Journal of Integrative Medicine, 1998,4(1):9-11.
Weibin, S., Hao, Z., Ning, D. et al. Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II., CJIM 4, 9–11 (1998). https://doi.org/10.1007/BF02935038 DOI：

Shi Weibin, Zhang Hao, Du Ning, et al. Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II[J]. Chinese Journal of Integrative Medicine, 1998,4(1):9-11. DOI： 10.1007/BF02935038.

摘要

Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism.Methods: Thirty-five women

49 to 62 years old

with 5.6 years menopause

were treated as the subjects and followed-up for 6 months

12 months or 24 months. The course of treatment ranged from 6 months to 25 months with an average of 14 months. Some related biochemical parameters

such as serum estradiol (E2)

testosterone (T)

the ratio of fasting urinary calcium to creatinine (Ca/Cr)

the ratio of 24h urinary calcium to creatinine (24h Ca/Cr)

24h urinary E2

and 24h urinary hydroxyproline (HOP) were measured before and after treatment.Results: After 6~9 months or 1~2 years of treatment

the levels of serum E2 and 24h urinary E2 were raised significantly

while the levels of serum T and urinary Ca/Cr fell evidently after one or two year’s treatment. The levels of serum E2 and 24h urinary E2 were significantly correlated with the levels of fasting urinary Ca/Cr

24h urinary Ca/Cr

serum T

and 24h urinary HOP respectively.Conclusions: Gusong-II can elevate the serum E2 levels of postmenopausal women

reduce the discharge of urinary calcium and HOP

and inhibit bone resorption. The rise of the serum E2 level might be correlated with the conversion of T to E2.

Abstract

Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism.Methods: Thirty-five women

49 to 62 years old

with 5.6 years menopause

were treated as the subjects and followed-up for 6 months

12 months or 24 months. The course of treatment ranged from 6 months to 25 months with an average of 14 months. Some related biochemical parameters

such as serum estradiol (E2)

testosterone (T)

the ratio of fasting urinary calcium to creatinine (Ca/Cr)

the ratio of 24h urinary calcium to creatinine (24h Ca/Cr)

24h urinary E2

and 24h urinary hydroxyproline (HOP) were measured before and after treatment.Results: After 6~9 months or 1~2 years of treatment

the levels of serum E2 and 24h urinary E2 were raised significantly

24h urinary Ca/Cr

serum T

and 24h urinary HOP respectively.Conclusions: Gusong-II can elevate the serum E2 levels of postmenopausal women

reduce the discharge of urinary calcium and HOP

and inhibit bone resorption. The rise of the serum E2 level might be correlated with the conversion of T to E2.

关键词

Gusong IIpostmenopausal osteoporosisbiochemical parameter

Keywords

Gusong IIpostmenopausal osteoporosisbiochemical parameter

references

1989; 44(5): 1021–1026.

1986; 6(10):598.

1992: 604–607.

1996; 4(4): 8–12.

E2 1994; 57–58.

1 1993: 355–388.

Takano-Yamamoto T, Rodan GA. Direct effects of 17 betaestradiol on tube rcular bone in ovariectomied rats. Proc Natl Acad Sci USA 1990; 87: 2172–2176.

FULL TEXT LINK

More>

浏览量

368

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Clinical practice guideline of traditional medicine for primary osteoporosis

Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

A clinical study of Yigu capsule in treating postmenopausal osteoporosis

Liuwei Dihuang Pill (六味地黄丸) Treats Postmenopausal Osteoporosis with Shen (Kidney) Yin Deficiency via Janus Kinase/Signal Transducer and Activator of Transcription Signal Pathway by Up-regulating Cardiotrophin-Like Cytokine Factor 1 Expression