Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis

Yi Zhong; Bing-Kuang Zhu; Shi-Fu Zheng

doi:10.1007/BF02935110

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Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis

OriginalPaper | Updated：2021-08-27

- Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis
- Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis
- 中国结合医学杂志（英文版） 2001年7卷第1期页码：43-47
- Affiliations：
  
  1. Guangdong Provincial TCM Hospital,Guangzhou
  2. Institute of Integrated Traditional Chinese and Western Medicine on Qi and Blood in Jinan University,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02935110
  中图分类号：
- 纸质出版日期：2001，
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Zhong, Y., Zhu, BK. & Zheng, SF. Experimental study of Yishou Tiaozhi tablet() on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis., CJIM 7, 43–47 (2001). https://doi.org/10.1007/BF02935110

Yi Zhong, Bing-Kuang Zhu, Shi-Fu Zheng. Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2001,7(1):43-47.
Zhong, Y., Zhu, BK. & Zheng, SF. Experimental study of Yishou Tiaozhi tablet() on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis., CJIM 7, 43–47 (2001). https://doi.org/10.1007/BF02935110 DOI：

Yi Zhong, Bing-Kuang Zhu, Shi-Fu Zheng. Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2001,7(1):43-47. DOI： 10.1007/BF02935110.

摘要

Objective: To observe the effect of Yishou Tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and atherosclerosis.Methods: Thirty-two rabbits were randomly divided into four groups

Group A

C and D

8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B

22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C

hyperlipid forage was given and for Group D

only ordinary forage was given. Biochemical parameters were measured and pathomorpho-logical examinations were carried out 6 weeks later.Results: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC)

triglyceride(TG)

atherosclerotic index(AI)

apoprotein(ApoB)

lipoprotein [Lp(a)]

oxygen-low density lipoprotein cholesterol (ox-LDL)

hydroxyproline(HYP)

plasma Ca2+

thromboxane B2 (TXB2)

and increased the levels of serum high-density lipoprotein cholesterol(HDL-C)

apoprotein A1 (Apo A1)

ApoA1/ApoB

plasma 6-keto-PGFlα (P < 0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced

smooth muscle cell hyperplasia and elastic fibers were not seen.Conclusion: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.

Abstract

Group A

C and D

8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B

22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C

hyperlipid forage was given and for Group D

triglyceride(TG)

atherosclerotic index(AI)

apoprotein(ApoB)

lipoprotein [Lp(a)]

oxygen-low density lipoprotein cholesterol (ox-LDL)

hydroxyproline(HYP)

plasma Ca2+

thromboxane B2 (TXB2)

and increased the levels of serum high-density lipoprotein cholesterol(HDL-C)

apoprotein A1 (Apo A1)

ApoA1/ApoB

plasma 6-keto-PGFlα (P < 0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced

关键词

Yishou Tiaozhi tablethyperlipemiaatherosclerosis

Keywords

Yishou Tiaozhi tablethyperlipemiaatherosclerosis

references

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Li ZJ, Han CS, Wang JX. Practical Radioimmunology. Beijing: The Scientific Technological Archive Publishing House, 1989: 198–221.

Gao YC. Effect of Yixing decoction on rats’ serum lipid level in hyperlipidemia and its mechanism. Academic Journal of Traditional Chinese Medicine 1990; (5): 53–56.

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Huang JG, translated. The atherosclerous lipid marker. Fascicle of Cardiovascular Disease in Journal of Foreign Medicine 1987; 14(1): 4–9.

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Chen SH. Hyperlipidemia and platelet high response. Fascicle of Cardiovascular Disease in Journal of Foreign Medicine 1989;16(5): 257–262.

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