Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ( ))

Zhou Xueping; Zhou Zhongying; Jin Miaowen; Guo Liwei; Fang Taihui; Wang Hong; Xu Huiqin; Wu Mianhua

doi:10.1007/BF02935162

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Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ( ))

OriginalPaper | Updated：2021-08-27

- Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ( ))
- Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ( ))
- 中国结合医学杂志（英文版） 1999年5卷第3期页码：165-170
- Affiliations：
  
  Nanjing University of Traditional Chinese Medicine,Nanjing
- Author bio：
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- DOI：10.1007/BF02935162
  中图分类号：
- 纸质出版日期：1999，
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Xueping, Z., Zhongying, Z., Miaowen, J. et al. Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ())., CJIM 5, 165–170 (1999). https://doi.org/10.1007/BF02935162

Zhou Xueping, Zhou Zhongying, Jin Miaowen, et al. Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ( ))[J]. Chinese Journal of Integrative Medicine, 1999,5(3):165-170.
Xueping, Z., Zhongying, Z., Miaowen, J. et al. Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ())., CJIM 5, 165–170 (1999). https://doi.org/10.1007/BF02935162 DOI：

Zhou Xueping, Zhou Zhongying, Jin Miaowen, et al. Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ( ))[J]. Chinese Journal of Integrative Medicine, 1999,5(3):165-170. DOI： 10.1007/BF02935162.

摘要

Objective: To explore the therapeutic mechanism of Shuguan Granule (

SGG) in treating mid-late stage rheumatoid arthritis (RA).Methods: Based on the principle of reinforcing Kidney to treat arthritis

removing phlegm to relieve stasis

two SGG

Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid-late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted.Results: The total effective rate of the SW

SQ and control group was 88.64%

93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant-induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase

and lowered the levels of serum interleukin-1

plasma prostaglandin E2 and thromboxane B2

as compared with the model group

the difference was significant (P < 0.05

P < 0.01).Conclusion: The two SGG have a comprehensive function of anti-inflammatory

analgesic

antioxidatory

antihypercoagulatory and immunoregulatory effect.

Abstract

Objective: To explore the therapeutic mechanism of Shuguan Granule (

SGG) in treating mid-late stage rheumatoid arthritis (RA).Methods: Based on the principle of reinforcing Kidney to treat arthritis

removing phlegm to relieve stasis

two SGG

SQ and control group was 88.64%

93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant-induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase

and lowered the levels of serum interleukin-1

plasma prostaglandin E2 and thromboxane B2

as compared with the model group

the difference was significant (P < 0.05

P < 0.01).Conclusion: The two SGG have a comprehensive function of anti-inflammatory

analgesic

antioxidatory

antihypercoagulatory and immunoregulatory effect.

关键词

rheumatoid arthritisShuguan Wenjing granuleShuguan Qingluo granuleanti-inflammationimmune function

Keywords

rheumatoid arthritisShuguan Wenjing granuleShuguan Qingluo granuleanti-inflammationimmune function

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