Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies

Liao Jing; Li Pingping; Wu Chunjing; E Zheng; Wang Shuzhen; Li Shulian

doi:10.1007/BF02935168

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Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies

OriginalPaper | Updated：2021-08-27

- Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies
- Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies
- 中国结合医学杂志（英文版） 1999年5卷第3期页码：185-189
- Affiliations：
  
  1. Capital University of Medical Sciences,Beijing
  2. Beijing Institute for Cancer Research,Beijing
  3. Norman Bethune University of Medical Sciences,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02935168
  中图分类号：
- 纸质出版日期：1999，
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Jing, L., Pingping, L., Chunjing, W. et al. Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies., CJIM 5, 185–189 (1999). https://doi.org/10.1007/BF02935168

Liao Jing, Li Pingping, Wu Chunjing, et al. Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies[J]. Chinese Journal of Integrative Medicine, 1999,5(3):185-189.
Jing, L., Pingping, L., Chunjing, W. et al. Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies., CJIM 5, 185–189 (1999). https://doi.org/10.1007/BF02935168 DOI：

Liao Jing, Li Pingping, Wu Chunjing, et al. Photosensitizer screening from Chinese medicinal herbs and photodynamic anticancer Studies[J]. Chinese Journal of Integrative Medicine, 1999,5(3):185-189. DOI： 10.1007/BF02935168.

摘要

Objective: To find new photosensitizers from Chinese medicinal herbs for cancer photodynamic therapy.Methods: The extracts of thirteen herbs were examined: (1) Their fluorescence excitation wave lengths and emission wave lengths; (2) Their fluorescence intensity in living cells and (3) Their distribution and localization in the living cells and the fixed cells both stained in each extract

and responses of cell fluorescence intensity to pH value change. Furthermore

the herb’s anticancer photosensitive efficiencies were studied by using BGC823 human stomach cancer cells.Results: Cortex Phellodendri and Rhizoma Coptidis

were found with optimal fluorescence properties as photosensitizers in this test. The latter could remarkably reduce the cell metabolic viability

proliferative ability and increase the cell mortality when the cells exposed to both drugs and luminance but not to drug only.Conclusions: The potential of Chinese medicine as a new kind of photosensitizer and its possibility for using in anticancer photodynamic therapy are existed.

Abstract

and responses of cell fluorescence intensity to pH value change. Furthermore

the herb’s anticancer photosensitive efficiencies were studied by using BGC823 human stomach cancer cells.Results: Cortex Phellodendri and Rhizoma Coptidis

were found with optimal fluorescence properties as photosensitizers in this test. The latter could remarkably reduce the cell metabolic viability

关键词

photodynamic anticancerChinese medicinal herbshuman stomach cancer cellsphotosensitizerscreening

Keywords

photodynamic anticancerChinese medicinal herbshuman stomach cancer cellsphotosensitizerscreening

references

Delaney TF, Glatstein ELI. Photodynamic therapy of cancer. Comprehensive Therapy 1988; 14(5): 43–55.

De Goeig AFPM, Ververgaert PHJT, Van Steveninck J. Photodynamic effects of protoporphyrin on the architecture of erythrocyte membranes in protoporphyria and in normal red blood cells. Clinica Chemica Acta 1975; 62: 287–292.

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Mosmann T. Rapid Colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. of Immunological Methods. 1983; 65: 55–63.

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Yoshimichi Sakai.1989; 4: 33.

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Tomson SH. Tumor destruction due to acridine orange photoactivation by argon laser. Ann NY Acad Sci 1976; 267: 191–198.

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