Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats

Ke Yongsheng; Liu Zhaofang; Zhao Zhendong

doi:10.1007/BF02935178

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Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats

OriginalPaper | Updated：2021-08-27

- Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats
- Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats
- 中国结合医学杂志（英文版） 1999年5卷第3期页码：214-215
- Affiliations：
  
  Yijishan Hospital, Wannan Medical College,Anhui
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- DOI：10.1007/BF02935178
  中图分类号：
- 纸质出版日期：1999，
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Yongsheng, K., Zhaofang, L. & Zhendong, Z. Effect of theo-polyphenols () on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats., CJIM 5, 214–215 (1999). https://doi.org/10.1007/BF02935178

Ke Yongsheng, Liu Zhaofang, Zhao Zhendong. Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats[J]. Chinese Journal of Integrative Medicine, 1999,5(3):214-215.
Yongsheng, K., Zhaofang, L. & Zhendong, Z. Effect of theo-polyphenols () on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats., CJIM 5, 214–215 (1999). https://doi.org/10.1007/BF02935178 DOI：

Ke Yongsheng, Liu Zhaofang, Zhao Zhendong. Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats[J]. Chinese Journal of Integrative Medicine, 1999,5(3):214-215. DOI： 10.1007/BF02935178.

摘要

Objective: To observe the effect of theo-polyphenols (TP) on function of trans-membranous signal of acute ischemic myocardium in rats.Methods: Model of myocardial ischemia was established. Thirtyfive male rats were randomly divided into 5 groups

7 rats in each group. Non-ischemic group: the anterior descending branch of left coronary artery was not ligated; Ischemic group: the time of ischemia continued for 10 min; TP groups: the groups were divided into 3 subgroups

TP dose was respectively 1 mg/kg

4 mg/kg

16 mg/kg

TP was administered through celiac injection 20 min before the anterior descending branch of left coronary artery was ligated.Results: The levels of phosphatidylinositol-4

5-biphosphate (PIP2)

inositol-1

5-triphosphate (IP3) in the ischemic group were markedly higher than those in the non-ischemic group. The raise of the levels of PIP2

IP3 caused by acute myocardial ischemia were markedly inhibited by the TP. The relationship of dose-effect was observed.Conclusion: TP has inhibitory effect of trans-membranous signal system of acute ischemic myocardium. It has protective effect on myocardium.

Abstract

TP dose was respectively 1 mg/kg

4 mg/kg

16 mg/kg

TP was administered through celiac injection 20 min before the anterior descending branch of left coronary artery was ligated.Results: The levels of phosphatidylinositol-4

5-biphosphate (PIP2)

inositol-1

5-triphosphate (IP3) in the ischemic group were markedly higher than those in the non-ischemic group. The raise of the levels of PIP2

关键词

Myocardial ischemiaphosphatidylinositol-45-biphosphateinositol-145-triphosphatetheo-polyphenols

Keywords

Myocardial ischemiaphosphatidylinositol-45-biphosphateinositol-145-triphosphatetheo-polyphenols

references

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