Objective: A comparative study on immunologic effects of Composite Prescription in Mice. Methods: Youguiyin prescription for tonifying Kidney)

Sijunzi Decoction ( for invigorating Spleen) and Taohong Siwu Decoction ( for promoting blood circulation) were conducted in mice aged 18 months and divided into 4 groups. The above-mentioned prescriptions were given to group I - III respectively. Group IV was kept untreated for aged control. Another group of 3 month-old mice was selected as the adult control. Results: T-

B-lymphocyte transformation rate and OKT3 lymphocyte

subgroup in the aged control group were distinctly lower than those in the adult control group. After 4 weeks treatment with different composite prescriptions

the T-

B-lymphocyte transformation rate of group II and III were evidently higher than those of the aged control group and OKT3 lymphocyte subgroup was distinctly lower in group I than that of group IV.Conclusions: The prescription of tonifying Kidney acted on immunal function of aged animals in a way different from that of prescriptions for invigorating Spleen or for promoting blood circulation.