Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection

Han Liya; Cai Dingfang

doi:10.1007/BF02935396

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Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection

OriginalPaper | Updated：2021-08-27

- Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection
- Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection
- 中国结合医学杂志（英文版） 1999年5卷第4期页码：257-260
- Affiliations：
  
  1. The Second People’s Hospital of Wenzhou City,Zhejiang
  2. Institute of Integrated Traditional Chinese and Western Medicine, Shanghai Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02935396
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- 纸质出版日期：1999，
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Liya, H., Dingfang, C. Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection., CJIM 5, 257 (1999). https://doi.org/10.1007/BF02935396

Han Liya, Cai Dingfang. Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection[J]. Chinese Journal of Integrative Medicine, 1999,5(4):257-260.
Liya, H., Dingfang, C. Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection., CJIM 5, 257 (1999). https://doi.org/10.1007/BF02935396 DOI：

Han Liya, Cai Dingfang. Clinical and experimental study on treatment of acute cerebral infarction with Acanthopanax Injection[J]. Chinese Journal of Integrative Medicine, 1999,5(4):257-260. DOI： 10.1007/BF02935396.

摘要

Objective: To evaluate the effect of Acanthopanacis Senticosi in treating acute cerebral infarction and its mechanism.Methods: Clinical study using single-blind

control trial

in which 60-80 ml of Acanthopanax Injection (AI) added to 500 ml of 0.9% normal saline were given by intravenous drip once a day for 14 days in the AI group

while 500 ml of low molecular dextran were given in the same way to the control group. In experimental study

rabbit model of acute incomplete cerebral ischemia was made by ligation of bilateral common carotid artery. 10 ml of AI were given once daily intravenously for 7 days to the AI group and 10 ml of normal saline was given to the control group in the same way. Clinical effects (in clinical study) and effect of AI on cerebral oxygen free radicals (OFR)

superoxide dismutase (SOD)

and serum concentration of ACTH and cortisone were all observed (in experimental study).Results: The total effective rate in the AI group was higher than that in the control group while nervous functional deficit score was lower in the AI group than that in the control group significantly. The cerebral level of OFR

serum level of ACTH and cortisone decreased while SOD increased after treatment in AI group.Conclusion: AI was effective in treating acute cerebral infarction

the mechanism is probably by ameliorating peroxidation in brain and improving hypothalamic-pituitary-a-drenocortical axis function.

Abstract

Objective: To evaluate the effect of Acanthopanacis Senticosi in treating acute cerebral infarction and its mechanism.Methods: Clinical study using single-blind

control trial

in which 60-80 ml of Acanthopanax Injection (AI) added to 500 ml of 0.9% normal saline were given by intravenous drip once a day for 14 days in the AI group

while 500 ml of low molecular dextran were given in the same way to the control group. In experimental study

superoxide dismutase (SOD)

serum level of ACTH and cortisone decreased while SOD increased after treatment in AI group.Conclusion: AI was effective in treating acute cerebral infarction

the mechanism is probably by ameliorating peroxidation in brain and improving hypothalamic-pituitary-a-drenocortical axis function.

关键词

Acanthopancis SeniticosiCerebral Infarctionoxygen free radical

Keywords

Acanthopancis SeniticosiCerebral Infarctionoxygen free radical

references

Lockwood CJ. The diagnosis of preterm labor and the prediction of preterm delivery. Clin-Obstet-Gynecol 1995; 38 (4):675–687.

Wong ML, Loddick SA, Bongiomo PB, et al. Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. Neuroreport 1995; 6(13): 1785–1788.

De Reuck J, Vandekerckhove J, Bosma G, et al. Steroid treatment in acute ischemic stroke: A comparative retrospective study of 556 cases. Eur Neurol 1988; 28: 70–72.

Sapolsky R, Pulsinelli WA. Glucocorticoids potentiate ischemic injury to neurons. Therapeutic implications. Science 1985; 229: 1397–1400.

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