Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract

Sun Baoliang; Xia Zuoli; Zheng Chengbi; Li Wenxia; Fang Yuzhen

doi:10.1007/BF02935404

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Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract

OriginalPaper | Updated：2021-08-27

- Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract
- Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract
- 中国结合医学杂志（英文版） 1999年5卷第4期页码：279-282
- Affiliations：
  
  Department of Neurology, Institute of Microcirculation, Affiliated Hospital of Taishan Medical College, Shangdong
- Author bio：
- Funds：
- DOI：10.1007/BF02935404
  中图分类号：
- 纸质出版日期：1999，
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Baoliang, S., Zuoli, X., Chengbi, Z. et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract., CJIM 5, 279–282 (1999). https://doi.org/10.1007/BF02935404

Sun Baoliang, Xia Zuoli, Zheng Chengbi, et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract[J]. Chinese Journal of Integrative Medicine, 1999,5(4):279-282.
Baoliang, S., Zuoli, X., Chengbi, Z. et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract., CJIM 5, 279–282 (1999). https://doi.org/10.1007/BF02935404 DOI：

Sun Baoliang, Xia Zuoli, Zheng Chengbi, et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract[J]. Chinese Journal of Integrative Medicine, 1999,5(4):279-282. DOI： 10.1007/BF02935404.

摘要

Objective: To investigate the role of endothelin-1 (ET-1) in development of ischemic brain damage after subarachnoid hemorrhage (SAH)

and the protective effect of Ginkgo biloba extract (GBE) on it.Methods: Noncraniotomy SAH models of Wistar rat were divided into SAH group and GBE treated group

the diameter of basilar artery (BA)

dynamic changes of regional cerebral blood flow (rCBF) and ET-1 content of in-tracranial plasma within 24 hours after SAH of both groups were determined. And pathological examination of CA1 region of hippocampus was performed 3 days later.Results: rCBF decreased and ET-1 content increased obviously and steadily in 24 hours after SAH. Spasm of BA occurred half an hour after SAH and neurons of hippocampus CA1 region were damaged severely. GBE could antagonize the above-mentioned pathological changes effectively

Abstract

Objective: To investigate the role of endothelin-1 (ET-1) in development of ischemic brain damage after subarachnoid hemorrhage (SAH)

and the protective effect of Ginkgo biloba extract (GBE) on it.Methods: Noncraniotomy SAH models of Wistar rat were divided into SAH group and GBE treated group

the diameter of basilar artery (BA)

关键词

subarachnoid hemorrhagecerebral vasospasmIschemic Brain DamageendothelinGinkgo Biloba Extract

Keywords

subarachnoid hemorrhagecerebral vasospasmIschemic Brain DamageendothelinGinkgo Biloba Extract

references

BedersonJB, Germano M, Guarino L. Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in rats. Strok 1995; 26: 1087–1097.

Veelken JA, Laing RJC, Takubouski J. The Sheffield model of subarachnoid hemorrhage in the rat. Strok 1995; 26: 1279–1283.

Hino A, Tokuyama Y, Kobayashi M, et al. Increased expression of endothelin B receptor mRNA following subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab 1996; 16: 688–697.

Zimmermann M, Seifert V, Loffler BM. Prevention of cerebral vasospasm after experimental subarachnoid hemorrhage by RO47 - 0203, a newly developed orally active endothelin receptor antagonist. Neurosurgery 1996; 38: 115–120.

Ziv I, Heminger G, Dyaldetti R, et al. Increased plasma endothelin 1 in acute ischemic stroke. Stroke 1992; 23: 1014–1026.

Kleijinen J, Kinpchild P. Ginkgo biloba. The Lancet 1992; 340: 1136–1139.

Oyama Y, Chilkahisa L, Toshiko U, et al. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Research 1996; 712: 349–352.

Shen JG, Zhou DY. Efficiency of ginkgo biloba extract (EGb761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochem Mol Biol Int 1995; 35: 125–133.

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