Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy

Wang Xian-Bo; Sang Yan; Han Qing; Guo Bao-Rui; Liu Xi-Xin

doi:10.1007/BF02935430

Your Location：

Home >

Browse articles >

Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy

OriginalPaper | Updated：2021-08-27

- Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy
- Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy
- 中国结合医学杂志（英文版） 1997年3卷第1期页码：21-25
- Affiliations：
  
  The First Affiliated Hospital of Xinxiang Medical College,Henan
- Author bio：
- Funds：
  
  Grant from Bureau of TCM of Henan Province
- DOI：10.1007/BF02935430
  中图分类号：
- 纸质出版日期：1997，
Scan for full text
Wang, XB., Sang, Y., Han, Q. et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy., CJIM 3, 21 (1997). https://doi.org/10.1007/BF02935430

Wang Xian-Bo, Sang Yan, Han Qing, et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy[J]. Chinese Journal of Integrative Medicine, 1997,3(1):21-25.
Wang, XB., Sang, Y., Han, Q. et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy., CJIM 3, 21 (1997). https://doi.org/10.1007/BF02935430 DOI：

Wang Xian-Bo, Sang Yan, Han Qing, et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy[J]. Chinese Journal of Integrative Medicine, 1997,3(1):21-25. DOI： 10.1007/BF02935430.

摘要

Objective: To study the effects of Chinese herbal medicine Tangshenkang (TSK) capsule on diabetic nephropathy (DN).Method: Fifty-seven patients with DN were randomly divided into two groups

the TSK-treated group and the control group-Results: Serious disorders of metabolism showed in DN patients

displayed high levels of thromboxane B2/6-keto-prostaglandin F1α(TXB2/6-keto-PGFlα) ratio and lipid peroxide (LPO) as compared with those of healthy persons. After 6 weeks treatment with TSK

the urinary albumin level reduced obviously (by 51%)

renal plasma flow (RPF) increased

glomerular filtration rate and LPO levels decreased. A positive correlation was observed between albuminuria level and TXB2/6-keto-PGFlα ratio. The clearance rate of creatinine didn’t improve significantly. In the control group

no significant difference in the above-mentioned parameters between pre-treatment and post-treatment was found.Conclusion: TSK capsule possessed a significant effect in improving urinary albumin and glomerular function. These effects might be due to the property of TSK in adjusting TXB2/6-keto-PGFlα ratio and its lipid-peroxidation in DN patients.

Abstract

Objective: To study the effects of Chinese herbal medicine Tangshenkang (TSK) capsule on diabetic nephropathy (DN).Method: Fifty-seven patients with DN were randomly divided into two groups

the TSK-treated group and the control group-Results: Serious disorders of metabolism showed in DN patients

displayed high levels of thromboxane B2/6-keto-prostaglandin F1α(TXB2/6-keto-PGFlα) ratio and lipid peroxide (LPO) as compared with those of healthy persons. After 6 weeks treatment with TSK

the urinary albumin level reduced obviously (by 51%)

renal plasma flow (RPF) increased

关键词

Tangshenkang capsulediabetic nephropathythromboxane B26-keto-prostaglandin Flα1lipid peroxide

Keywords

Tangshenkang capsulediabetic nephropathythromboxane B26-keto-prostaglandin Flα1lipid peroxide

references

Mogesen CE, Christensen CK. The diabetic kidney from hyperfiltration and microalbumin to end-stage renal failure. Med Clin Nor Am 1988; 72: 1465–1469.

1987; 3(4): 196–198.

1989: 430–432,451–455.

1986;6 (2):152–154.

1989;9(1): 46–47.

Anderson S. Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations. Diabetes Metab Rev 1988; 4: 163–165.

1989: 565–566.

1994;10(1): 19–21.

1991; 31(7): 402–404.

FULL TEXT LINK

More>

浏览量

379

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats

Study on the relationship between chinese medicine constitutive susceptibility and diversity of syndrome in diabetic nephropathy

Regulation of C-type natriuretic peptides and natriuretic peptide receptor-B expression in diabetic rats renal treated by Tongluo Recipe (通络方)

Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

Effects of panax notoginoside on the nephropathy in rats with type 1 diabetes mellitus