Objective: To find effective therapeutic approach for treating true idiopathic precocious puberty suitable to our national condition and different from gonadotrophin releasing hormone analogue.Methods: One hundred and six girls with idiopathic precocious puberty were divided into 3 groups. The 51 girls in the TCM-WM group were treated with Chinese herbal medicine combined with megestrol acetate (MA)

35 girls in the MA group treated with megestrol acetate alone

and 20 girls were taken as control group and given no treatment at all. Luteinizing hormone releasing hormone (LHRH) stimulating test were performed before and after treatment

and the size of the uterus and ovary

linear growth rate

X-ray bone age measurement and final height prediction were also observed simultaneously.Results: After treated with TCM-WM for 2.7 years in average

the luteinizing hormone (LH) peak value of LHRH stimulating test was reduced from 48.5 ± 5.2 IU/L to 12. 2 ± 1.3 IU/L

size of uterus and ovary decreased

secondary sexual characteristics regressed

the bone age difference/chronological age difference value (ΔBA/ΔCA) reduced from 1.35 ± 0.09 to 0.65 ± 0.05 and predictive final height increased from 153.3 ± 0.5 cm to 158.5 ± 0.6 cm.Conclusion: TCM-WM therapy could not only modulate the function of hypothalamic-pituitary-ovarian axis and the development of internal genitalia

but also could decelerate skeletal growth

delay skeletal maturation

and thereby prevent premature epiphyseal fusion and increase the final height of patients.