Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits

Wang Zhiwei; Gao Shangzhi; Cheng Bangchang; Lin Daoming; Yao Zhen; Tu Zhongfan

doi:10.1007/BF02935480

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Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits

OriginalPaper | Updated：2021-08-27

- Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits
- Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits
- 中国结合医学杂志（英文版） 1998年4卷第4期页码：282-285
- Affiliations：
  
  The First Affiliated Hospital of Hubei Medical University,Wuhan
- Author bio：
- Funds：
- DOI：10.1007/BF02935480
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- 纸质出版日期：1998，
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Zhiwei, W., Shangzhi, G., Bangchang, C. et al. Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits., CJIM 4, 282–285 (1998). https://doi.org/10.1007/BF02935480

Wang Zhiwei, Gao Shangzhi, Cheng Bangchang, et al. Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits[J]. Chinese Journal of Integrative Medicine, 1998,4(4):282-285.
Zhiwei, W., Shangzhi, G., Bangchang, C. et al. Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits., CJIM 4, 282–285 (1998). https://doi.org/10.1007/BF02935480 DOI：

Wang Zhiwei, Gao Shangzhi, Cheng Bangchang, et al. Experimental study on therapeutic effect of combined administration of Radix Salviae Miltiorrhizae, ligustrazine and Radix Sanchi on late hemorrhagic shock of rabbits[J]. Chinese Journal of Integrative Medicine, 1998,4(4):282-285. DOI： 10.1007/BF02935480.

摘要

Objective: To explore the therapeutic mechanism of the combined use of Radix Salviae Miltiorrhizae

ligustrazine and Radix Sanchi in treating late hemorrhagic shock in rabbit.Methods: Rabbit hemorrhagic shock models were set up according to Wiggers’ method and treated with the combined therapy. Levels of RBC superoxide dismutase (SOD) activity

plasma malondialdehyde (MDA)

blood lactate (BL) and magnesium (Mg++) were continuously monitored before shock

120 minutes after shock

60 and 120 minutes after reinfusion.Results: (1) Levels of SOD decreased and MDA

Mg++ increased markedly 120 minutes after shock

indicating that there existed cell membrane damage caused by oxygen free radicals in hemorrhagic shock. (2) The combination therapy could alleviate lipid peroxidation injury to tissue

enhance the activity of SOD and lower the concentration of MDA significantly

P < 0.01 or 0.05

as compared with the control group.Conclusion: The combined use of the three drugs could gain the same effect with half dosage as that gained from the whole dosage of one single drug. It could also reduce the negative effect of treatment

such as hypotension and slowing down of heart rate

Abstract

Objective: To explore the therapeutic mechanism of the combined use of Radix Salviae Miltiorrhizae

plasma malondialdehyde (MDA)

blood lactate (BL) and magnesium (Mg++) were continuously monitored before shock

120 minutes after shock

60 and 120 minutes after reinfusion.Results: (1) Levels of SOD decreased and MDA

Mg++ increased markedly 120 minutes after shock

indicating that there existed cell membrane damage caused by oxygen free radicals in hemorrhagic shock. (2) The combination therapy could alleviate lipid peroxidation injury to tissue

enhance the activity of SOD and lower the concentration of MDA significantly

P < 0.01 or 0.05

such as hypotension and slowing down of heart rate

关键词

Hemorrhagic shockRadix Salviae MiltiorrhizaeLigustrazineRadix Sanchicombined administration

Keywords

Hemorrhagic shockRadix Salviae MiltiorrhizaeLigustrazineRadix Sanchicombined administration

references

Mccord JM. Oxygen-derived free radicals in postischemic tissue injury. New Eng J Med 1985;312(3): 159–163.

Ehrich FE, Kramer SG, Watkins E. An experimental shock model simulating clinical hemorhagic shock. Surg Gynecol Obstet Dec 1969; 129(6): 1173–1180.

Prasad K, Kaira J, Buchko G. Acute hemorrhage and oxygen free radicals. Angiology 1988; 39(12): 1005–1013.

Bond RF. The effect of allopurinol and catalase on cardiovascular hemodynamics during hemorrhagic shock. Circ Shock 1988; 25(3): 139–151.

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