Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

Duan Shaobin; Luo Ji’an; Liu Ruihong; Xu Xiping

doi:10.1007/BF02935483

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Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

OriginalPaper | Updated：2021-08-27

- Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure
- Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure
- 中国结合医学杂志（英文版） 1998年4卷第4期页码：290-292
- Affiliations：
  
  1. The Second Affiliated Hospital of Hunan Medical University,Changsha
  2. Department of Electron Microscope, Hunan Medical University,Changsha
- Author bio：
- Funds：
  
  This work was supported by the grant from the Health Administration of Hunan Province
- DOI：10.1007/BF02935483
  中图分类号：
- 纸质出版日期：1998，
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Shaobin, D., Ji’an, L., Ruihong, L. et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure., CJIM 4, 290–292 (1998). https://doi.org/10.1007/BF02935483

Duan Shaobin, Luo Ji’an, Liu Ruihong, et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure[J]. Chinese Journal of Integrative Medicine, 1998,4(4):290-292.
Shaobin, D., Ji’an, L., Ruihong, L. et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure., CJIM 4, 290–292 (1998). https://doi.org/10.1007/BF02935483 DOI：

Duan Shaobin, Luo Ji’an, Liu Ruihong, et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure[J]. Chinese Journal of Integrative Medicine, 1998,4(4):290-292. DOI： 10.1007/BF02935483.

摘要

Objective: Radiographic contrast media can induce renal failure and it may serve as an experimental model of acute renal failure (ARF). The study was aimed to determine the protective effect of Shengmai Injection (SMI) on contrast medium-associated ARF in Sprague-Dawley (SD) rats.Methods: Twenty healthy SD rats of both sex were randomly divided into two groups

Group A (control group) treated with glycerin+0. 9% saline+meglucamine diatrizoate

and group B (preventive group) with glycerin+SMI+meglucamine diatrizoate.Results: In Group B

the levels of blood urea nitrogen

serum creatinine

renal phospholipase A2 (PLA2) and calcium were all significantly lower than those in Group A

P < 0.01. The results indicated the renal injury induced by meglucamine diatrizoate was alleviated by SMI.Conclusion: SMI could prevent renal tissue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracellular calcium accumulation

inhibiting PLA2 activity and dilating renal vessels.

Abstract

Group A (control group) treated with glycerin+0. 9% saline+meglucamine diatrizoate

and group B (preventive group) with glycerin+SMI+meglucamine diatrizoate.Results: In Group B

the levels of blood urea nitrogen

serum creatinine

renal phospholipase A2 (PLA2) and calcium were all significantly lower than those in Group A

inhibiting PLA2 activity and dilating renal vessels.

关键词

nephrotoxicitycontrast mediaShengmai Injectionrenal failuremeglucamine diatrizoate

Keywords

nephrotoxicitycontrast mediaShengmai Injectionrenal failuremeglucamine diatrizoate

references

Porter GA. Effect of contrast agent on renal function. Invest Radiol 1993; 28: S1-S5.

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