Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia

Tao Yue-yu; Guo Song-duo; Chen Hui-zheng; Hu Hua; Lu Bu-feng; Yan Yu-lan; Lu You-ming

doi:10.1007/BF02940701

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Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia

OriginalPaper | Updated：2021-08-27

- Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia
- Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia
- 中国结合医学杂志（英文版） 1995年1卷第4期页码：288-290
- Affiliations：
  
  1. Nanjing Hospital of Navy,Nanjing,414
  2. Nanjing Research Center of Neuro-biology of Navy,China
- Author bio：
- Funds：
- DOI：10.1007/BF02940701
  中图分类号：
- 纸质出版日期：1995，
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Tao, Yy., Guo, Sd., Chen, Hz. et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia., CJIM 1, 288–290 (1995). https://doi.org/10.1007/BF02940701

Tao Yue-yu, Guo Song-duo, Chen Hui-zheng, et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia[J]. Chinese Journal of Integrative Medicine, 1995,1(4):288-290.
Tao, Yy., Guo, Sd., Chen, Hz. et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia., CJIM 1, 288–290 (1995). https://doi.org/10.1007/BF02940701 DOI：

Tao Yue-yu, Guo Song-duo, Chen Hui-zheng, et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia[J]. Chinese Journal of Integrative Medicine, 1995,1(4):288-290. DOI： 10.1007/BF02940701.

摘要

Using the model of acute myocardial ischemia in rats formed by ligation of the descending anterior branch of the left coronary artery

this study showed some effects of compound Salviae miltiorrhizae injection (CSMI) on metabolism of phosphoinositide in myocardial ischemia. The results of the experiment showed that after 10 minutes of acute ischemia

the function of myocardial messangers of phosphoinositide increased

and the levels of phosphatidylinositol-4

5-biphosphate (PIP2) and inositol-1

5-trisphosphate (IP3) were obviously higher than those of the non-ischemia control groups (P<0.01

n=7). CSMI (2 g/kg body weight) could markedly inhibit myocardial PIP2 and IP3

whose levels became lower than those of the ischemia control groups (P<0.01

n=7).

Abstract

Using the model of acute myocardial ischemia in rats formed by ligation of the descending anterior branch of the left coronary artery

the function of myocardial messangers of phosphoinositide increased

and the levels of phosphatidylinositol-4

5-biphosphate (PIP2) and inositol-1

5-trisphosphate (IP3) were obviously higher than those of the non-ischemia control groups (P<0.01

n=7). CSMI (2 g/kg body weight) could markedly inhibit myocardial PIP2 and IP3

whose levels became lower than those of the ischemia control groups (P<0.01

n=7).

关键词

Myocardial ischemiaphophoinositidescompound Salviae miltiorrhizae injection

Keywords

Myocardial ischemiaphophoinositidescompound Salviae miltiorrhizae injection

references

Dun W, et al. Anti-arrhythmia and anti-lipid peroxidation effects of methylflavonolamine. Acta Pharmacol Sin 1991;12:177.

Lowry OH, et al. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:2550.

Willerson JJ, et al. Specific platelet mediators and unstable coronary artery lessions. Circulation 1989;80:198.

James JW, et al. Pathogenesis and pathology of ischemic heart disease. In: James JW, L’Daid H, L’Marimilian B, eds. Ischemic heart disease: clinical and pathophysiological aspects. New York: Raven Press, 1982:7–83.

Hokin LE. Receptors and phosphoinositide-generated second messangers. Am Rev Biolchem 1985;54:205.

Putney JW Jr. Formation and action of calcium-mobilizing messenger, inositol-1, 4, 5-trisphosphate. Am J Physiol 1987;252:G149.

Heathers GP, et al. Enhanced inositol trisphosphates response to alpha 1-adrenergic stimulation in cardiac myocytes exposed to hypoxia. J Clin Invest 1989; 83:1409.

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