The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus

Zhao Xiao-zhong; Liu Fu-ren

doi:10.1007/BF02942761

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The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus

OriginalPaper | Updated：2021-08-27

- The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus
- The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus
- 中国结合医学杂志（英文版） 1995年1卷第2期页码：111-113
- Affiliations：
  
  1. Department of Dermatology, General Air Force Hospital,Beijing
  2. Department of Dermatology, 2nd Affiliated Hospital of Xi’an Medical University,Xi’an
- Author bio：
- Funds：
- DOI：10.1007/BF02942761
  中图分类号：
- 纸质出版日期：1995，
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Zhao, Xz., Liu, Fr. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus., CJIM 1, 111–113 (1995). https://doi.org/10.1007/BF02942761

Zhao Xiao-zhong, Liu Fu-ren. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus[J]. Chinese Journal of Integrative Medicine, 1995,1(2):111-113.
Zhao, Xz., Liu, Fr. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus., CJIM 1, 111–113 (1995). https://doi.org/10.1007/BF02942761 DOI：

Zhao Xiao-zhong, Liu Fu-ren. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus[J]. Chinese Journal of Integrative Medicine, 1995,1(2):111-113. DOI： 10.1007/BF02942761.

摘要

The natural killer cell activity of peripheral blood mononuclear cells from 28 patients with systemic lupus erythematosus was measured using enzyme-release assay. The patients exhibited obviously decreased natural killer cell activity compared with the healthy subjects in the control group. The natural killer cell dysfunction was related to steroidal therapy

but not to three auto-antibodies. The release of a soluble natural killer cytotoxic factor by the peripheral blood mononuclear cells was tested by cytotoxicity assay induced in K562 cells. This release was significantly lower in the test group than in the control group. Pre-incubation of peripheral blood mononuclear cells withAstragalus membranaceus andTripterygium hypoglaucum considerably enhanced natural killer cytotoxicity by stimulating the release of soluble cytotoxic factors.

Abstract

关键词

Astragalus membranaceusTripterygium hypoglaucumnatural killer cell activitynatural killer cytotoxic factorsystemic lupus erythematosus

Keywords

Astragalus membranaceusTripterygium hypoglaucumnatural killer cell activitynatural killer cytotoxic factorsystemic lupus erythematosus

references

Tan E, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271.

Barada F, et al. Antibodies to Sm patients with SLE: Correlation of Sm antibody titers with disease activity and other laboratory parameters. Arthritis Rheum 1981;24:1236.

Korzeuiewski C, et al. An enzyme-release assay for natural cytotoxicity. J Immunol Meth 1983;64:313.

Sibbitt E, et al. Impaired release of a soluble natural killer cytotoxic factor in SLE. Arthritis Rheum 1984;27:1095.

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