Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

Hao Xu; Dazhuo Shi; Keji Chen; Xiaochang Ma; Yongli Li; Liang Meng; Weimin Yuan

doi:10.1007/BF02947380

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Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

OriginalPaper | Updated：2021-08-27

- Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model
- Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model
- 中国结合医学杂志（英文版） 2000年6卷第4期页码：278-282
- Affiliations：
  
  1. Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM,Beijing
  2. Department of Experimental Surgery, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences,China
- Author bio：
- Funds：
  
  Part of a National Ninth-Five Planning Project (No. 96-9060601)
- DOI：10.1007/BF02947380
  中图分类号：
- 纸质出版日期：2000，
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Xu, H., Shi, D., Chen, K. et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model., CJIM 6, 278–282 (2000). https://doi.org/10.1007/BF02947380

Hao Xu, Dazhuo Shi, Keji Chen, et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model[J]. Chinese Journal of Integrative Medicine, 2000,6(4):278-282.
Xu, H., Shi, D., Chen, K. et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model., CJIM 6, 278–282 (2000). https://doi.org/10.1007/BF02947380 DOI：

Hao Xu, Dazhuo Shi, Keji Chen, et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model[J]. Chinese Journal of Integrative Medicine, 2000,6(4):278-282. DOI： 10.1007/BF02947380.

摘要

Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups

untreated or treated with probucol

Xueguantong

low and high dose of XSC respectively

and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group

all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 )

both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling

and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery.

Abstract

untreated or treated with probucol

Xueguantong

low and high dose of XSC respectively

all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 )

and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery.

关键词

Xiongshao capsuleangioplastyrestenosisvascular remodeling

Keywords

Xiongshao capsuleangioplastyrestenosisvascular remodeling

references

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