Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats

Saimei Li; Manqi Xiong; Anzhong Lin; Qingwen Xu; Haixia Zheng; Yongzhen Hu; Min He

doi:10.1007/BF02947384

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Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats

OriginalPaper | Updated：2021-08-27

- Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats
- Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats
- 中国结合医学杂志（英文版） 2000年6卷第4期页码：290-294
- Affiliations：
  
  Guangzhou University of TCM,Guangzhou
- Author bio：
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- DOI：10.1007/BF02947384
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- 纸质出版日期：2000，
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Li, S., Xiong, M., Lin, A. et al. Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats., CJIM 6, 290–294 (2000). https://doi.org/10.1007/BF02947384

Saimei Li, Manqi Xiong, Anzhong Lin, et al. Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats[J]. Chinese Journal of Integrative Medicine, 2000,6(4):290-294.
Li, S., Xiong, M., Lin, A. et al. Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats., CJIM 6, 290–294 (2000). https://doi.org/10.1007/BF02947384 DOI：

Saimei Li, Manqi Xiong, Anzhong Lin, et al. Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats[J]. Chinese Journal of Integrative Medicine, 2000,6(4):290-294. DOI： 10.1007/BF02947384.

摘要

Objective: To compare the preventive effect of treatment with different methods of traditional Chinese medicine(TCM) for myocardial ischemia caused by coronary artery ligation in diabetic rats.Methods:Animal models established by streptozotocin plus coronary artery ligation were treated by modified Taoren Chengqi Decoction (MTRCQD) and different combinations of its ingredients respectively

and the effects on ischemia area

occurrence of arrhythmia

T-wave in ECG and 2 hrs post-operational survival rate were observed and compared.Results: MTRCQD and different combinations of its ingredients could reduce the area of ischemia and elevate survival rate significantly (P<0.05–0.01)

especially in the group treated with MTRCQD plus leech. Improvement of T-wave was shown in the groups treated with MTRCQD or with MTRCQD plus leech.Conclusion: TCM treatment of invigorating Qi

nourishing Yin

purging Heat and activating blood circulation is an effective treatment for diabetic coronary heart disease.

Abstract

and the effects on ischemia area

occurrence of arrhythmia

especially in the group treated with MTRCQD plus leech. Improvement of T-wave was shown in the groups treated with MTRCQD or with MTRCQD plus leech.Conclusion: TCM treatment of invigorating Qi

nourishing Yin

purging Heat and activating blood circulation is an effective treatment for diabetic coronary heart disease.

关键词

Traditional Chinese Medicine Treatmentcoronary artery ligationMyocardial ischemiadiabetic rats

Keywords

Traditional Chinese Medicine Treatmentcoronary artery ligationMyocardial ischemiadiabetic rats

references

Zheng GF, Li SM, Xiong MQ, et al. Electron microscopic research of the effect of various parts of Added-Tao- He-Chen-Qi-Tang on myocardial pathological change of diabetic rat. Practical J of Integrated Traditional Chinese and Western Med 1998;11(24):2368–2369.

Xu SY, Bian RL, Chen X, edit. Methodology of Pharmacological Experiment. Beijing: People’s Health Publishing House, 2nd edition 1994:921,938.

Wu KG. Clinical treatment of diabetic cardiovascular disease. J Practical Int Med 1991; 11(12):631–632.

Qian QH. Practical knowledge on therapy and hygiene of diabetes mellitus. Jinan, Shandong University Publishing House. 1993:293.

Su AD. Effect of Jiangtang Tongmaining on serum and tissue oxygen free radicals in diabetic rats. CJIM 1993; 13(5):291–293.

Xiong MQ, Liang LW, Lin AZ, et al. Clinical and experimental study on Modified Taohe Chengqi decoction in treating diabetes mellitus type II. CJIM 1992; 12(2):74- 76.

Li SM, Xiong MQ, Lin AZ, et al. Preliminary observation on the blockage of hyperglycemia, hyperlipemia and insulin resistance in diabetic rats by different treatment. Chinese J of Basic Med in TCM 1999; 5(8):34–37.

Zheng Gf, Li Sm, Xiong Mq, et al. Ultramicrostructural pathological change of STZ induced diabetic rats. Academical J of Wuhan University 1997; (8):129–130.

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