Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ

Na Liu; Pingping Zuo; Fenghua Liu; Hongyu Xue

doi:10.1007/BF02950928

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Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ

OriginalPaper | Updated：2021-08-27

- Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ
- Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ
- 中国结合医学杂志（英文版） 2000年6卷第3期页码：200-203
- Affiliations：
  
  Institute of Basic Medicine, Peking Union Medical College,Beijing
- Author bio：
- Funds：
  
  ΔThis program was supported by National Nature Science Foundation of China (No.39421012)
- DOI：10.1007/BF02950928
  中图分类号：
- 纸质出版日期：2000，
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Liu, N., Zuo, P., Liu, F. et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ., CJIM 6, 200–203 (2000). https://doi.org/10.1007/BF02950928

Na Liu, Pingping Zuo, Fenghua Liu, et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ[J]. Chinese Journal of Integrative Medicine, 2000,6(3):200-203.
Liu, N., Zuo, P., Liu, F. et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ., CJIM 6, 200–203 (2000). https://doi.org/10.1007/BF02950928 DOI：

Na Liu, Pingping Zuo, Fenghua Liu, et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ[J]. Chinese Journal of Integrative Medicine, 2000,6(3):200-203. DOI： 10.1007/BF02950928.

摘要

Objective: To observe the behavioral and biochemical effects of a traditional Chinese medicine Huanshao Dan (HSD) on learning and memory deficits in transient cerebral ischemia model in mice.Methods: Step-through experiments

receptor binding test and choline acetyltransferase (ChAT) activities determination were performed.Results: Mice undertaken transient ischemia commited much more mistakes in step-through experiments and showed relatively higher3 H-MK801 binding in cerebral cortex and hippocampus than in sham operated animals. HSD decoction was most effective in reducing these mistakes in mice. At the same time

and3 H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased

while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity.

Abstract

and3 H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased

while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity.

关键词

Huanshao Danexcitoxintransient cerebral ischemiaN-methyl-D-Aspartic acid receptorcholine acyltransferase

Keywords

Huanshao Danexcitoxintransient cerebral ischemiaN-methyl-D-Aspartic acid receptorcholine acyltransferase

references

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