Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis

Rui-Lin Li; Pei-Lin Liu; Xu-Chu Wu; Jian-Jun Wei; Li-Hua Xia

doi:10.1007/BF02969658

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Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis

OriginalPaper | Updated：2021-08-27

- Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis
- Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis
- 中国结合医学杂志（英文版） 1996年2卷第2期页码：111-114
- Affiliations：
  
  1. Honghu Institute of Rheumatic Disease,Hubei
  2. Tongji Hospital of Tongji Medical University,Wuhan
  3. Affiliated Hospital of Hubei Medical College of TCM,Wuhan
  4. Wuhan No. 9 Pharmaceutical Factory,Wuhan
- Author bio：
- Funds：
- DOI：10.1007/BF02969658
  中图分类号：
- 纸质出版日期：1996，
Scan for full text
Li, RL., Liu, PL., Wu, XC. et al. Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis., CJIM 2, 111–114 (1996). https://doi.org/10.1007/BF02969658

Rui-Lin Li, Pei-Lin Liu, Xu-Chu Wu, et al. Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 1996,2(2):111-114.
Li, RL., Liu, PL., Wu, XC. et al. Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis., CJIM 2, 111–114 (1996). https://doi.org/10.1007/BF02969658 DOI：

Rui-Lin Li, Pei-Lin Liu, Xu-Chu Wu, et al. Clinical Study on sustained release tablet of tripterygium Wilfordii in treating rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 1996,2(2):111-114. DOI： 10.1007/BF02969658.

摘要

Adopting prospective

multi-center

random

single-blind and equal rank-control methods

226 patients with rheumatoid arthritis (RA) were divided into two groups. The 114 patients of the test group were treated with oral sustained release tablets of Tripterygium Wilfordii (TW-SR)

2 tablets twice a day for 4 weeks

112 patients of the control group received tablets of Tripterygium Wilfordii (TW) orally 2 tablets 3 times per day for 4 weeks. Testing results showed the total effective rates of the two groups were 92.11 % and 90.65 %

respectively (P>0.05). The adverse reaction rate of TW-SR was 20.18%

which was lower than that of TW group of 70.54% (P<0. 01). Results of pre-clinical pharmacologic experimental study demonstrated that TW-SR has obvious anti-inflammatory

analgesic and immunosuppressive actions the same as TW

while the toxicity of TW-SR was less than that of TW significantly.

Abstract

Adopting prospective

multi-center

random

single-blind and equal rank-control methods

226 patients with rheumatoid arthritis (RA) were divided into two groups. The 114 patients of the test group were treated with oral sustained release tablets of Tripterygium Wilfordii (TW-SR)

2 tablets twice a day for 4 weeks

respectively (P>0.05). The adverse reaction rate of TW-SR was 20.18%

which was lower than that of TW group of 70.54% (P<0. 01). Results of pre-clinical pharmacologic experimental study demonstrated that TW-SR has obvious anti-inflammatory

analgesic and immunosuppressive actions the same as TW

while the toxicity of TW-SR was less than that of TW significantly.

关键词

rheumatoid arthritisTripterygium Wilfordiisustained release tablet of Tripterygium Wilfordii

Keywords

rheumatoid arthritisTripterygium Wilfordiisustained release tablet of Tripterygium Wilfordii

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