The effect of herbal medicine preparation Composite Donyuan Gao (CDYG) on the animal model of drug dependence was studied. After the morphinistic models of white rats and mice had been made by closes of morphine which were ever increased daily and each time

the animals were divided into large dose CDYG group

small dose CDYG group

sustained morphine group and the control group. The withdrawal symptoms were observed after naloxone was given to the animal intraperitoneally. The results showed that in the CDYG groups withdrawal symptoms of the addicted white rats were alleviated

the number of jumps of the addicted mice was reduced

the scores of the principal symptoms of the animals were decreased

while the animals gained soon in weight. Comparing with the control group

the difference was significant (P<0.01). The fact that the effect of the CDYG was enhanced in the large dose group

suggests that it was dosage dependent.