Antioxidative effects of rubidate on ischemic myocardium in mice

Sheng-Li Yang; Fa Liu; Si-Ya A; Rui-Fen Cheng

doi:10.1007/BF02969671

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Antioxidative effects of rubidate on ischemic myocardium in mice

OriginalPaper | Updated：2021-08-27

- Antioxidative effects of rubidate on ischemic myocardium in mice
- Antioxidative effects of rubidate on ischemic myocardium in mice
- 中国结合医学杂志（英文版） 1996年2卷第2期页码：139-140
- Affiliations：
  
  Department of Pharmacology, Xinjiang Medical College,Urumqi
- Author bio：
- Funds：
- DOI：10.1007/BF02969671
  中图分类号：
- 纸质出版日期：1996，
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Yang, SL., Liu, F., A, SY. et al. Antioxidative effects of rubidate on ischemic myocardium in mice., CJIM 2, 139 (1996). https://doi.org/10.1007/BF02969671

Sheng-Li Yang, Fa Liu, Si-Ya A, et al. Antioxidative effects of rubidate on ischemic myocardium in mice[J]. Chinese Journal of Integrative Medicine, 1996,2(2):139-140.
Yang, SL., Liu, F., A, SY. et al. Antioxidative effects of rubidate on ischemic myocardium in mice., CJIM 2, 139 (1996). https://doi.org/10.1007/BF02969671 DOI：

Sheng-Li Yang, Fa Liu, Si-Ya A, et al. Antioxidative effects of rubidate on ischemic myocardium in mice[J]. Chinese Journal of Integrative Medicine, 1996,2(2):139-140. DOI： 10.1007/BF02969671.

摘要

Rubidate is a phenolic compound. The present investigation was designed to establish whether rubidate protects the heart muscle against the deleterious effects of the oxygen free radicals produced by isoproterenol (ISO)-induced myocardial ischemia in mice. ISO treatment (30 mg kg-1 subcutaneous injection once daily for 2 days) caused widespread and severe myocardial cell damage

decreased myocardial glutathione peroxidase (GSH-Px)

superoxide dismutase (SOD) activities and increased myocardial malondialdehyde (MDA) content. Rubidate pretreatment 500 mg-kg-1

2000 mg.kg-1×7d protected GSH-Px

SOD activity in the hearts of ISO-treated mice. Rubidate 2000 mg-kg-1 diminished MDA production. However

rubidate 500 mg.kg-1 did not show such an effect. This study demonstrated that rubidate inhibited lipid peroxidation (LPO

expressed by malondialdehyde formation)

scavenged-Oz - and H2O2. It may be concluded that rubidate exhibits an antioxidative activity via scavenging free radicals.

Abstract

decreased myocardial glutathione peroxidase (GSH-Px)

superoxide dismutase (SOD) activities and increased myocardial malondialdehyde (MDA) content. Rubidate pretreatment 500 mg-kg-1

2000 mg.kg-1×7d protected GSH-Px

SOD activity in the hearts of ISO-treated mice. Rubidate 2000 mg-kg-1 diminished MDA production. However

rubidate 500 mg.kg-1 did not show such an effect. This study demonstrated that rubidate inhibited lipid peroxidation (LPO

expressed by malondialdehyde formation)

scavenged-Oz - and H2O2. It may be concluded that rubidate exhibits an antioxidative activity via scavenging free radicals.

关键词

rubidateisoproterenolmyocardial ischemia damagelipid peroxidationsuperoxide dismutaseglutathione peroxidasemalondialdehydeantioxidation

Keywords

rubidateisoproterenolmyocardial ischemia damagelipid peroxidationsuperoxide dismutaseglutathione peroxidasemalondialdehydeantioxidation

references

Hussain SJ, Jahan M, Asif M, et al. Beneficial effect of Taxus baccata, L. in experimental myocardial necrosis. Planta Medica 1977; 32: 133.

Das DK, Engelman RM, Rousou JA, et al. Pathophysiology of superoxide radical as potent mediator of reperfusion injury in pig heart. Basic Res Cardiol 1986; 81: 151.

Burton GW. Biological antioxidants. In: Hill H eds. Inorganic and organic radical: their biological and clinical relevance. Cambridge University Press, 1985: 115–128.

Ball SS, Weindruch R, Walford RL. Antioxidants and the immune response. In: Johnson HE, et al. eds. Free radicals, aging and degenerative disease. New Yoek: Alan R Liss Inc. 1986: 427–457.

Yang SI, Liu F, Hu J. Immune suppressive effect of ru-bidate. In: Xie MZ, Zhu XY, Cheng GF, et al. eds. Programme and abstracts. The Third China-Japan Joint Meeting on Pharmacology, Beijing: 1993; May.

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