Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia

Qian Zuqi; Lu Huijuan; Wu Ping; Liu Xilian; Xin Leina; Dai Haili; Zhang Kejing; Lu Rongfa

doi:10.1007/BF02970571

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Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia

OriginalPaper | Updated：2021-08-27

- Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia
- Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia
- 中国结合医学杂志（英文版） 2000年6卷第2期页码：96-100
- Affiliations：
  
  1. Maternity and Child Care Centre of Nanshi District,Shanghai
  2. Obstetrics and Gynaecology Hospital, Shanghai Medical University,China
  3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences,China
- Author bio：
- Funds：
- DOI：10.1007/BF02970571
  中图分类号：
- 纸质出版日期：2000，
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Qian, Z., Lu, H., Wu, P. et al. Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia., CJIM 6, 96–100 (2000). https://doi.org/10.1007/BF02970571

Qian Zuqi, Lu Huijuan, Wu Ping, et al. Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia[J]. Chinese Journal of Integrative Medicine, 2000,6(2):96-100.
Qian, Z., Lu, H., Wu, P. et al. Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia., CJIM 6, 96–100 (2000). https://doi.org/10.1007/BF02970571 DOI：

Qian Zuqi, Lu Huijuan, Wu Ping, et al. Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia[J]. Chinese Journal of Integrative Medicine, 2000,6(2):96-100. DOI： 10.1007/BF02970571.

摘要

Objective: To explore the therapeutic mechanism of Bushen Yugong Granule (BSYGG

a Chinese medicinal preparation) in treating infertility due to uterine dysgenesia.Methods: (1) Clinical study: Serum level of sex hormone and endometrial contents of estradial receptor (ER) and progesterone receptor (PR) in follicle period of 60 patients (the tested group) were measured and compared before and after treatment

and also compared with those of 70 normal women (the control group). (2) Experimental study: Rats were divided into the control group and 3 tested groups fed with different doses of BSYGG. Pathologic examination of pituitary

ovary and uterus of rats after BSYGG treatment were performed

and serum levels of ER

PR measured. Also

an estrogen activity experiment was conducted in some young oophorectomized rats.Results: (1) Clinical study showed the difference of serum sex hormone levels between the tested and control group was insignificant. The percentage of patients in the tested groups with endometrial ER content over ++ was lower than that in the control group (46.9 % vs 72.4 %) significantly (P < 0.05)

after treatment

it rose to 65.4 %

and the change was significant

P<0.05. (2) Experimental study showed that the number of follicle

weight of uterus and serum E2 level increased significantly after BSYGG treatment. The endometrial content of ER in the control group was 29.25±17.03%

while in the tested groups

it was 67.75 ± 24.56% to 83.00 ± 9.87% after treatment

the difference between the two groups was significant (P<0.005).Conclusion: BSYGG has an estrogen-like activity

it could increase the endometrial content of ER

enhance the effect of estrogen on uterus and promote the development of uterus

so as to elevate fertilization rate.

Abstract

Objective: To explore the therapeutic mechanism of Bushen Yugong Granule (BSYGG

ovary and uterus of rats after BSYGG treatment were performed

and serum levels of ER

PR measured. Also

after treatment

it rose to 65.4 %

and the change was significant

P<0.05. (2) Experimental study showed that the number of follicle

weight of uterus and serum E2 level increased significantly after BSYGG treatment. The endometrial content of ER in the control group was 29.25±17.03%

while in the tested groups

it was 67.75 ± 24.56% to 83.00 ± 9.87% after treatment

the difference between the two groups was significant (P<0.005).Conclusion: BSYGG has an estrogen-like activity

it could increase the endometrial content of ER

enhance the effect of estrogen on uterus and promote the development of uterus

so as to elevate fertilization rate.

关键词

Bushen Yugong Granuleuterine dysgenesiaInfertilitysex hormone receptor

Keywords

Bushen Yugong Granuleuterine dysgenesiaInfertilitysex hormone receptor

references

Qian Zhuqi, Gao Miaozhen, Chen Yixin, et al. Clinical observation on treatment of 223 cases of uterine dysgenesia caused infertility by integrated traditional Chinese and western medicine. Shanghai J of TCM, 1997; (9): 28–31.

Zhou Yongchang, Guo Wanxue, edited in chief. Ultrasound Medicine. 1st edition. Beijing: Beijing Publishing House of Scientific and Technologic Literatures, 1991:817.

Lu Xiaomei, Chen Shuyuan, Huang Shoufang, et al. Exploration on method and positive data evaluation of estrogen receptor in paraffin section of mammary cancer. Chinese J Pathology, 1996;25(12):330.

Wang Shuzhen edited in chief. Practical Gynecotokology. 1st edition. Beijing. People’s Health Publishing House, 1992:32.

Lu Shiming, Chen Qiubo, Zhou Ciguan, et al. Effect of L-18-methylnorethindrone intra – uterine contraceptive device on receptors of estrogen and progesterone. Chinese J of Obstetrics and Gynecology, 1991;26(5): 293–294.

Lin Youju, Chen Yusheng, Han Xinming, et al. Effect of Warming-Yang Drugs on uterine female sex hormone receptor in hypothalamus-pituitary gland-adrenal cortex axis inhibition model rats. CJIM 1985;5(3): 175–177.

Xiao Donghong, Yang Shoufan. Experimental study on Yuyinling and receptors of estrogen and progesterone. TianjinJ TCM,1996:13(1):33–34.

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