Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats

Sun Fei; Yu Jin

doi:10.1007/BF02970584

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Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats

OriginalPaper | Updated：2021-08-27

- Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats
- Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats
- 中国结合医学杂志（英文版） 2000年6卷第2期页码：127-130
- Affiliations：
  
  Obstetric and Gynecologic Hospital, Shanghai Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02970584
  中图分类号：
- 纸质出版日期：2000，
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Sun, F., Yu, J. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats., CJIM 6, 127–130 (2000). https://doi.org/10.1007/BF02970584

Sun Fei, Yu Jin. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats[J]. Chinese Journal of Integrative Medicine, 2000,6(2):127-130.
Sun, F., Yu, J. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats., CJIM 6, 127–130 (2000). https://doi.org/10.1007/BF02970584 DOI：

Sun Fei, Yu Jin. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats[J]. Chinese Journal of Integrative Medicine, 2000,6(2):127-130. DOI： 10.1007/BF02970584.

摘要

Objective: To explore the effect of Tiangui Recipe (TGR) on obesity and reproductive function in androgen-sterilized rats (ASR).Methods: ASR model was established by subcutaneous injection of testosterone propionate to SD female rats at the age of 9 days. Change of serum leptin

follicular stimulating hormone (FSH) and luteinizing hormone (LH) in model rats aged 115 days before and after feeding them with TGR was measured by radioimmunoassay (RIA). Meanwhile

criteria of energy state

including diurnal food intake

retroperitoneal fat depot weight and body weight

were measured and evaluated.Results: ASR had the characteristics of high metabolic rate

energy imbalance and obesity. Serum level of leptin increased and FSH

LH decreased significantly (P<0.01) in model rats as compared with the normal rats. Significant positive correlation between leptin level and body weight (r=0.8977

P<0.001) was observed

and negative correlation was seen between FSH

LH and leptin (r = -0.7517

P<0.001; r= -0.8444

P<0.001

respectively). The endocrine changes of ASR all returned to normal range after the TGR treatment.Conclusion: Obesity and concerned hypogonadotrophic hypogonadal anovulation were expressed in ASR. TGR may play an important role in reducing weight and inducing ovulation.

Abstract

follicular stimulating hormone (FSH) and luteinizing hormone (LH) in model rats aged 115 days before and after feeding them with TGR was measured by radioimmunoassay (RIA). Meanwhile

criteria of energy state

including diurnal food intake

retroperitoneal fat depot weight and body weight

were measured and evaluated.Results: ASR had the characteristics of high metabolic rate

energy imbalance and obesity. Serum level of leptin increased and FSH

LH decreased significantly (P<0.01) in model rats as compared with the normal rats. Significant positive correlation between leptin level and body weight (r=0.8977

P<0.001) was observed

and negative correlation was seen between FSH

LH and leptin (r = -0.7517

P<0.001; r= -0.8444

P<0.001

关键词

Tiangui Recipeandrogen-sterilized ratleptinPituitary Gonadotropin

Keywords

Tiangui Recipeandrogen-sterilized ratleptinPituitary Gonadotropin

references

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