Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats

Shi Haiming; Luo Xingping; Zeng Zhiyu; Fan Weihu; Dai Ruihong

doi:10.1007/BF02970586

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Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats

OriginalPaper | Updated：2021-08-27

- Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats
- Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats
- 中国结合医学杂志（英文版） 2000年6卷第2期页码：131-133
- Affiliations：
  
  Cardiac Division, Huashan Hospital, Shanghai Medical University,Shanghai
- Author bio：
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- DOI：10.1007/BF02970586
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- 纸质出版日期：2000，
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Shi, H., Luo, X., Zeng, Z. et al. Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats., CJIM 6, 131–133 (2000). https://doi.org/10.1007/BF02970586

Shi Haiming, Luo Xingping, Zeng Zhiyu, et al. Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats[J]. Chinese Journal of Integrative Medicine, 2000,6(2):131-133.
Shi, H., Luo, X., Zeng, Z. et al. Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats., CJIM 6, 131–133 (2000). https://doi.org/10.1007/BF02970586 DOI：

Shi Haiming, Luo Xingping, Zeng Zhiyu, et al. Study on effect of astragalus on left ventricular collagen remodeling after myocardial infarction in rats[J]. Chinese Journal of Integrative Medicine, 2000,6(2):131-133. DOI： 10.1007/BF02970586.

摘要

Objective: To study the effect of Astragalus (As) on left ventricular collagen remodeling after myocardial infarction in rats.Methods: Myocardial collagen (MC) and ratio of myocardial collagen type I and M in rat models of myocardial infarction treated with Astragalus injection were determined and compared with those in sham operated rats and in captopril(CAP) treated rats.Results: MC and ratio of MC I /IE of non-in-farcted region in the myocardial infarction rats was higher than that in the sham group. Both AS and CAP could restrain the ascending trend of these parameters.Conclusion: Astragalus is effective in lowering the elevation of MC after infarction and changing the MC I /H ratio

therefore

is beneficial to improve the systolic and diastolic function of left ventricle after acute myocardial infarction.

Abstract

therefore

is beneficial to improve the systolic and diastolic function of left ventricle after acute myocardial infarction.

关键词

Astragalusacute myocardial infarctionmyocardial collagenCaptoprilventricular function

Keywords

Astragalusacute myocardial infarctionmyocardial collagenCaptoprilventricular function

references

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Eghbali M, Weber KT. Collagen and the myocardium: fibrillar structure biosynthesis and degradation in relation to hypertrophy and its regression. Mol Cell Biochem 1990;96: 1–5.

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