Objective: To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and Ticlid in treating early diabetic nephropathy (DN).Method: Fifty-eight patients were divided randomly into two groups

28 patients of the Ticlid group treated with Ticlid 250 mg orally

once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. The therapeutic effect and relative indexes of the two groups were observed and compared.Results: After treatment

in both groups

the thromboxane B2 markedly reduced and was more prominent in the Ticlid group (P<0.05)

while the 6-keto-prostaglandin F1α increased obviously

so as to cause a significant lowering of T/K ratio

P<0. 01. Levels of urinary albumin

β2 microglobulin and blood ±1 microglobulin of both groups were lowered significantly

P<0. 01. A significant positive linear correlation was found in the Ticlid group between urinary albumin and T/K ratio (r = 0.41

P < 0.01)

as well as in blood ±1 microglobulin with T/K ratio (r = 0. 34

P < 0.05)

while it was not found in the PNG group.Conclusion: Ticlid and PNG were beneficial to resume the balance of T/K ratio and improve microcirculation

reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN.