Objective: To observe the effect of puerarin on superoxide dismutase (SOD)

lipid peroxidation (LPO)

tissue plasminogen (TPA) and plasminogen activator inhibitor (PAI-1) of coronary heart disease (CHD) patients.Methods: Forty-eight patients were divided into two groups (treated group and control group). Treated group was given intravenously 600 mg puerarin

once daily for one week

also the same treatment as that of control was given. Nitrite colorimetric method

radioimmunoassay (RIA)

TBA fluorescent development process and fibrinolysin specific colorbase substrate decomposition development process were used to determine SOD activity

SOD

LPO

TPA and PAI-1.Results: After the treatment with puerarin

SOD activity was increased

LPO reduced

while without any changes in the control group. There was insignificant changes of SOD between the treated and the control groups. TPA and PAI-1 were increased significantly in the treated group

but was insignificantly changed in the control group.Conclusion: Puerarin can increase the SOD activity

decrease LPO level and enhance the activity of fibrinolysis.