Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM-WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism.Methods: Ninety-one repeatedly recurrent CPN patients were randomly divided into 2 groups

the control group (45 cases) treated with sufficient amount of sensitive antibiotics and other WM

the treated group (46 cases) treated with above-mentioned WM complemented with TCM syndrome differentiation (SD).Results: In the treated group completely cured was 14 cases (30.4%)

markedly effective 14 cases (30.4%)

the total effective rate was 91.3%; while that of the control group was 4 (8.9%)

5 (11.1%)

and 48.9% respectively

(P < 0.05) and (P < 0.01); the mean days of urinary bacteria and urinary routine negative conversion were in the treated group 19.6±12.6 days and 24.3±11.5 days

obviously shorter than those of the control group (35.6±14.6 days and 53.6±16.4 days)

P<0.01; the various symptoms of the treated group improved or disappeared in a short time

while in the control group a few patients improved in a longer period (P < 0.01); the various immune parameters improved in the treated group

while in the control group only IgA was elevated to some extent (P < 0.05)

in comparing these data

the difference was significant (P < 0.01).Conclusion: The TCM-WM integrative treatment could obviously raise the clinical efficacy

accelerate the symptom improvement

and enhance the immune function.