Effect of emodin on biological behavior of fibroblasts in lupus nephritis

Liu Guan-xian M. D.; Ye Ren-gao; Tan Zhi-ming; Zhong Wei-qiang; Yang Yong-ming; Zhang Guo-qiang; Fang Jing-ai

doi:10.1007/BF03178490

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Effect of emodin on biological behavior of fibroblasts in lupus nephritis

OriginalPaper | Updated：2021-08-27

- Effect of emodin on biological behavior of fibroblasts in lupus nephritis
- Effect of emodin on biological behavior of fibroblasts in lupus nephritis
- 中国结合医学杂志（英文版） 2001年7卷第3期页码：205-208
- Affiliations：
  
  1. Department of Nephrology, Huizhou Central People’s Hospital, Huizhou City
  2. Institute of Nephrology, Sun Yat-sen University of Medical Science, People’s Republic of China
  3. The First Affiliated Hospital, Shanxi Medical University, People’s Republic of China
- Author bio：
- Funds：
- DOI：10.1007/BF03178490
  中图分类号：
- 纸质出版日期：2001，
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Liu, Gx., Ye, Rg., Tan, Zm. et al. Effect of emodin on biological behavior of fibroblasts in lupus nephritis., CJIM 7, 205 (2001). https://doi.org/10.1007/BF03178490

Liu Guan-xian M. D., Ye Ren-gao, Tan Zhi-ming, et al. Effect of emodin on biological behavior of fibroblasts in lupus nephritis[J]. Chinese Journal of Integrative Medicine, 2001,7(3):205-208.
Liu, Gx., Ye, Rg., Tan, Zm. et al. Effect of emodin on biological behavior of fibroblasts in lupus nephritis., CJIM 7, 205 (2001). https://doi.org/10.1007/BF03178490 DOI：

Liu Guan-xian M. D., Ye Ren-gao, Tan Zhi-ming, et al. Effect of emodin on biological behavior of fibroblasts in lupus nephritis[J]. Chinese Journal of Integrative Medicine, 2001,7(3):205-208. DOI： 10.1007/BF03178490.

摘要

Objective: To observe the effect of emodin on the biological behavior of human fibroblasts (FB) in culture of kidney in patients with lupus nephritis (LN).Methods: FB were isolated from kidney culture of LN patients

and the effect of emodin on3H-TdR incorporated rate of FB was observed. The apoptosis and c-myc gene expression were detected in the same way by flow cytometry.Results: Emodin could markedly inhibit the proliferation of human kidney FB

and inducing cell apoptosis through up-regulating c-myc gene expression in human renal FB.Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB

which may be important in ameliorating interstitial fibrosis

and thus improve prognosis of LN.

Abstract

and inducing cell apoptosis through up-regulating c-myc gene expression in human renal FB.Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB

which may be important in ameliorating interstitial fibrosis

and thus improve prognosis of LN.

关键词

Emodinfibroblastproliferationapoptosisc-myc protein

Keywords

Emodinfibroblastproliferationapoptosisc-myc protein

references

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Rodemann HP, Muller GA. Characterization of human, renal fibroblasts in health and disease: II In vitro growth, differentiation and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. Am J Kidney Dis 1991;17:684–686.

Elstei KH, Zucker RM. Comparison of cellular and nuclear flow cytometric technique for discriminating apoptotic subpopulation. Exp Cell Res 1994;211:322–323.

John Savill. Apoptosis: A mechanism for regulation of the cell complement of inflamed glomeruli. Kidney Int 1992;47:607–612.

Xigang Wufu. Bioactivity of Rhubarb and its active principle. Foreign Med Chinese Drug Fascicle 1986;8(3):27–30.

LIU ZH, HU WX, LI LS, et al. Effect of emodin on renal mesangium cell proliferation cell antigen. J Nephropathy Dialysis and Renal Transplant 1993;2:45–48.

YE RG, SUN L. Further develop the TCM-WM in studying on lupus nephritis. Chin J Integr Med 1997;17(3):177–178.

WEI LB, LIU GX, chief edited. Clinical experience of Dr. YE Ren-gao on nephropathy. Beijing: People’s Health Publishing House, 1997:183–190.

GAO XS, CHEN FX. For the sake of health of all mankind use rhubarb. Chin J Integr Med (Chin) 1990;10(12):754–757.

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