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Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica
Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica
- 中国结合医学杂志（英文版） 2001年7卷第3期 页码：209-213
- Affiliations：
Department of Biochemistry, College of Medicine, Yanbian University, Yanji
- Author bio：
- Funds：This work was supported by a grant from the National Natural Science Foundation of China (No. 39660021)
DOI：10.1007/BF03178491
中图分类号：纸质出版日期：2001，
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Yin, Zz., Jin, Hl., Yin, Xz. et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica, ., CJIM 7, 209 (2001). https://doi.org/10.1007/BF03178491
Yin Zong-zhu M. D., Jin Hai-ling, Yin Xue-zhe, et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica[J]. Chinese Journal of Integrative Medicine, 2001,7(3):209-213.
Yin, Zz., Jin, Hl., Yin, Xz. et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica, ., CJIM 7, 209 (2001). https://doi.org/10.1007/BF03178491 DOI：
Yin Zong-zhu M. D., Jin Hai-ling, Yin Xue-zhe, et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica[J]. Chinese Journal of Integrative Medicine, 2001,7(3):209-213. DOI： 10.1007/BF03178491.
摘要
Objective: To investigate the anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica (BR).Methods: The expression of tumor marker
GST-P
p53 and p21ras proteins in promotion stage of rat chemical hepatocarcinogenesis were examined by immunohistochemical technique ABC method. Anti-tumor effect of BR was investigated by inhibitory test on Sarcoma180. Anti-inflammatory activity of BR was tested by xylene-induced mouse ear swelling method.Results: BR-H2O extract (the H2O extract fractionated from BR-Methanol extract with CH2Cl2 and H2O) 500 mg/kg has inhibitory effect on the formation of diethylnitrosamine (DEN)-induced glutathione S-transferase placental form (GST-P) positive foci in rat liver with the expression of mutant p53 and p21ras proteins lower than those of non-treated hepatic preneoplastic lesions. BR extract showed inhibitory effect on Sarcoma180 and anti-inflammatory effect in mice by xylene-induced mouse ear swelling tests.conclusion: BR-H2O extract exerted inhibitory effect on DEN-induced preneoplastic hepatic foci in promotion stage of rat chemical hepatocarcinogenesis and might suppress the growth of solid Sarcoma180 in mice. Both CH2Cl2 and H2O extract from BR exerted anti-inflammatory effect in mice.
Abstract
Objective: To investigate the anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica (BR).Methods: The expression of tumor marker
GST-P
p53 and p21ras proteins in promotion stage of rat chemical hepatocarcinogenesis were examined by immunohistochemical technique ABC method. Anti-tumor effect of BR was investigated by inhibitory test on Sarcoma180. Anti-inflammatory activity of BR was tested by xylene-induced mouse ear swelling method.Results: BR-H2O extract (the H2O extract fractionated from BR-Methanol extract with CH2Cl2 and H2O) 500 mg/kg has inhibitory effect on the formation of diethylnitrosamine (DEN)-induced glutathione S-transferase placental form (GST-P) positive foci in rat liver with the expression of mutant p53 and p21ras proteins lower than those of non-treated hepatic preneoplastic lesions. BR extract showed inhibitory effect on Sarcoma180 and anti-inflammatory effect in mice by xylene-induced mouse ear swelling tests.conclusion: BR-H2O extract exerted inhibitory effect on DEN-induced preneoplastic hepatic foci in promotion stage of rat chemical hepatocarcinogenesis and might suppress the growth of solid Sarcoma180 in mice. Both CH2Cl2 and H2O extract from BR exerted anti-inflammatory effect in mice.
关键词
Boschniakia rossicaplacental form glutathione S-transferasep53chemical hepatocarcinogenesisSarcoma180anti-inflammation
Keywords
Boschniakia rossicaplacental form glutathione S-transferasep53chemical hepatocarcinogenesisSarcoma180anti-inflammation
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